| Title: |
Central- and peripheral-line-associated bloodstream infections in Victorian neonatal intensive care units: findings from a comprehensive Victorian surveillance network, 2008–2024 |
| Authors: |
Liu, ZR; Bull, AL; Phuong, LK; Malloy, MJ; Friedman, ND; Worth, LJ |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2025 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: Neonates face a high risk of healthcare-associated bloodstream infections, leading to increased morbidity and mortality. Effective surveillance is crucial for safe neonatal care and infection prevention. AIM: To evaluate infection trends, pathogen distribution and antimicrobial resistance patterns in central- and peripheral-line-associated bloodstream infections (CLABSIs and PLABSIs) in Victorian Level 6 neonatal intensive care units between 1st July 2008 and 30th June 2024. METHODS: Data were collected by the Victorian Healthcare Associated Infection Surveillance System Coordinating Centre using Centers for Disease Control and Prevention National Healthcare Safety Network guidelines. A retrospective data analysis of prospectively collected data was conducted to examine infection epidemiology. FINDINGS: Overall, 581 neonates developed CLABSIs or PLABSIs, corresponding to a mean CLABSI rate of 2.26 per 1000 central-line-days and a mean PLABSI rate of 0.60 per 1000 peripheral-line-days. The median age at diagnosis of all events was 16 days (interquartile range 9-35 days). No trends were observed in CLASBI or PLABSI rates over the study period. However, an increasing trend in CLABSI rates [incidence risk ratio (IRR) 1.04, 95% confidence interval (CI) 1.00-1.07; P=0.043] and a decreasing trend in PLABSI rates (IRR 0.95, 95% CI 0.92-0.99; P=0.021) were noted among neonates with birth weight ≤750 g. The most frequently reported organisms were coagulase-negative staphylococci, responsible for 44.0% of CLABSIs and 39.5% of PLABSIs. CONCLUSION: Neonatal intensive care units in Victoria maintained low CLABSI and PLABSI rates over the study period. Higher infection rates in low-birthweight neonates emphasize the need for targeted infection prevention strategies for this vulnerable population. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0195-6701 |
| Relation: |
https://hdl.handle.net/11343/366013 |
| Availability: |
https://hdl.handle.net/11343/366013 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.8F051E6B |
| Database: |
BASE |