| Title: |
Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. A long term follow-up |
| Authors: |
Colom, Alejandro J; Maffey, Alberto; Bournissen, Facundo Garcia; Teper, Alejandro |
| Publisher Information: |
BMJ Publishing Group Ltd |
| Publication Year: |
2015 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Paediatric lung disease |
| Description: |
Background Postinfectious bronchiolitis obliterans (BO) is a chronic respiratory disease that usually follows a severe adenovirus infection. Objective To determine the evolution of pulmonary function and clinical outcome of children with postinfectious BO during childhood. Methods The study included patients diagnosed with postinfectious BO in whom at least two spirometries were performed within a minimum interval of 3 months. Results 46 met the inclusion criteria. The mean (±SD) follow-up period was 12.5 (±3.5) years. 197 spirometries and 41 plethysmographies were performed. Initial (9±3 years old) lung function was as follows (z score, mean±SD): forced vital capacity (FVC) −3.8±1; forced expiratory volume in 1 s (FEV 1 ) −4.4±1; FEV 1 /FVC −2.2±1; forced expiratory flow (FEF) 25–75 −3.7±1; total lung capacity (TLC) 120±26%; residual volume (RV) 309±108%; and RV/TLC 55±13. During childhood, FVC and FEV 1 increased by a mean of 11%/year (95% CI 9.3% to 12.6%; p |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://thorax.bmj.com/cgi/content/short/70/2/169; http://dx.doi.org/10.1136/thoraxjnl-2014-205328 |
| DOI: |
10.1136/thoraxjnl-2014-205328 |
| Availability: |
http://thorax.bmj.com/cgi/content/short/70/2/169; https://doi.org/10.1136/thoraxjnl-2014-205328 |
| Rights: |
Copyright (C) 2015, BMJ Publishing Group Ltd |
| Accession Number: |
edsbas.8F19BFE8 |
| Database: |
BASE |