| Title: |
Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: Baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481] |
| Authors: |
Keech, AC; Scott, R; Best, J; Forder, P; Taskinen, MR; Simes, J; Barter, P; Colman, P; d'Emden, M; Davis, T; Drury, P; Ehnholm, C; Glasziou, P; Hunt, D; Kesaniemi, YA; Laakso, M; Simes, RJ; Sullivan, D; Whiting, M; Ansquer, JC; Fraitag, B; Anderson, N; Hankey, G; Lehto, S; Mann, S; Romo, M; Li, LP; Hennekens, C; MacMahon, S; Pocock, S; Tonkin, A; Wilhelmsen, L; Akauola, H; Alford, F; Beinart, I; Bohra, S; Boyages, S; Connor, H; Darnell, D; Davoren, P; Lepre, F; De Looze, F; Duffield, A; Fassett, R; Flack, J; Fulcher, G; Grant, S; Hamwood, S; Harmelin, D; Jackson, R; Jeffries, W; Kamp, M; Kritharides, L; Mahar, L; McCann, V; McIntyre, D; Moses, R; Newnham, H; Nicholson, G; O'Brien, R; Park, K; Petrovsky, N; Phillips, P; Pinn, G; Simmons, D; Stanton, K; Stuckey, B; Sullivan, DR; Suranyi, M; Suthers, M; Tan, Y; Templer, M; Topliss, D; Waites, JH; Watts, G; Welborn, T; Wyndham, R; Haapamaki, H; Kesaniemi, A; Lahtela, J; Levanen, H; Saltevo, J; Sodervik, H; Taskinen, M; Vanhala, M; Baker, J; Burton, A; Dixon, P; Doran, J; Dunn, P; Graham, N; Hamer, A; Hedley, J; Lloyd, J; Manning, P; McPherson, I; Morris, S; Barter, Philip; Powell, Madeleine |
| Source: |
urn:ISSN:1475-2840 ; Cardiovascular Diabetology, 4, 1 |
| Publisher Information: |
BioMed Central Ltd. |
| Publication Year: |
2005 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; Diabetes; Prevention; Cardiovascular; Obesity; Clinical Research; Heart Disease - Coronary Heart Disease; Atherosclerosis; Clinical Trials and Supportive Activities; Aging; Nutrition; Heart Disease; 6.1 Pharmaceuticals; Metabolic and endocrine; 3 Good Health and Well Being; Aged; Apolipoproteins B; Australia; Cardiovascular Diseases; Cholesterol; HDL; LDL; Coronary Disease; Diabetes Complications; Diabetes Mellitus; Type 2; Double-Blind Method; Female; Fenofibrate |
| Description: |
Objective: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study is examining the effects of long-term fibrate therapy on coronary heart disease (CHD) event rates in patients with diabetes mellitus. This article describes the trial's run-in phase and patients' baseline characteristics. Research design and methods: FIELD is a double-blind, placebo-controlled trial in 63 centres in 3 countries evaluating the effects of fenofibrate versus placebo on CHD morbidity and mortality in 9795 patients with type 2 diabetes mellitus. Patients were to have no indication for lipid-lowering therapy on randomization, but could start these or other drugs at any time after randomization. Follow-up in the study was to be for a median duration of not less than 5 years and until 500 major coronary events (fatal coronary heart disease plus nonfatal myocardial infarction) had occurred. Results: About 2100 patients (22%) had some manifestation of cardiovascular disease (CVD) at baseline and thus high risk status. Less than 25% of patients without CVD had a (UKPDS determined) calculated 5-year CHD risk of |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_67268 |
| DOI: |
10.1186/1475-2840-4-13 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_67268; https://unsworks.unsw.edu.au/bitstreams/16a1f20b-3ccc-4366-8fac-11a3df339b98/download; https://doi.org/10.1186/1475-2840-4-13 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read |
| Accession Number: |
edsbas.8F1A59DF |
| Database: |
BASE |