| Title: |
Sugar-sweetened beverages, low/no-calorie beverages, fruit juice and non-alcoholic fatty liver disease defined by fatty liver index: the SWEET project |
| Authors: |
Naomi, ND; Ngo, J; Brouwer-Brolsma, EM; Buso, MEC; Soedamah-Muthu, SS; Pérez-Rodrigo, C; Harrold, JA; Halford, JCG; Raben, A; Geleijnse, JM; Serra-Majem, L; Feskens, EJM |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2023 |
| Collection: |
The University of Liverpool Repository |
| Description: |
Background: Sweetened beverage intake may play a role in non-alcoholic fatty liver disease (NAFLD) development, but scientific evidence on their role is limited. This study examined associations between sugar-sweetened beverages (SSB), low/no-calorie beverages (LNCB) and fruit juice (FJ) intakes and NAFLD in four European studies. Methods: Data for 42,024 participants of Lifelines Cohort, NQPlus, PREDIMED-Plus and Alpha Omega Cohort were cross-sectionally analysed. NAFLD was assessed using Fatty Liver Index (FLI) (≥60). Restricted cubic spline analyses were used to visualize dose–response associations in Lifelines Cohort. Cox proportional hazard regression analyses with robust variance were performed for associations in individual cohorts; data were pooled using random effects meta-analysis. Models were adjusted for demographic, lifestyle, and other dietary factors. Results: Each additional serving of SSB per day was associated with a 7% higher FLI-defined NAFLD prevalence (95%CI 1.03–1.11). For LNCB, restricted cubic spline analysis showed a nonlinear association with FLI-defined NAFLD, with the association getting stronger when consuming ≤1 serving/day and levelling off at higher intake levels. Pooled Cox analysis showed that intake of >2 LNCB servings/week was positively associated with FLI-defined NAFLD (PR 1.38, 95% CI 1.15–1.61; reference: non-consumers). An inverse association was observed for FJ intake of ≤2 servings/week (PR 0.92, 95% CI: 0.88–0.97; reference: non-consumers), but not at higher intake levels. Theoretical replacement of SSB with FJ showed no significant association with FLI-defined NAFLD prevalence (PR 0.97, 95% CI 0.95–1.00), whereas an adverse association was observed when SSB was replaced with LNCB (PR 1.12, 95% CI 1.03–1.21). Conclusions: Pooling results of this study showed that SSB and LNCB were positively associated with FLI-defined NAFLD prevalence. Theoretical replacement of SSB with LNCB was associated with higher FLI-defined NAFLD prevalence. An inverse association was ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2044-4052 |
| Relation: |
https://livrepository.liverpool.ac.uk/3171618/1/Sugar-sweetened%20beverages,%20lowno-calorie%20beverages,%20fruit%20juice%20and%20non-alcoholic%20fatty%20liver%20disease%20defined%20by%20fatty%20liver.pdf; Collapse authors list. Naomi, ND orcid:0000-0001-8141-4907 , Ngo, J, Brouwer-Brolsma, EM, Buso, MEC, Soedamah-Muthu, SS, Pérez-Rodrigo, C orcid:0000-0002-4554-6184 , Harrold, JA orcid:0000-0002-0899-4586 , Halford, JCG, Raben, A orcid:0000-0001-5229-4491 , Geleijnse, JM orcid:0000-0001-7638-0589 et al (show 2 more authors) , Serra-Majem, L orcid:0000-0002-9658-9061 and Feskens, EJM orcid:0000-0001-5819-2488 (2023) Sugar-sweetened beverages, low/no-calorie beverages, fruit juice and non-alcoholic fatty liver disease defined by fatty liver index: the SWEET project Nutrition and Diabetes, 13 (1). 6-. ISSN 2044-4052, 2044-4052 |
| DOI: |
10.1038/s41387-023-00237-3 |
| Availability: |
https://livrepository.liverpool.ac.uk/3171618/; https://doi.org/10.1038/s41387-023-00237-3 |
| Accession Number: |
edsbas.8F351D6A |
| Database: |
BASE |