| Title: |
Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis |
| Authors: |
Razazi, Keyvan; Luyt, Charles-Edouard; Voiriot, Guillaume; Rouzé, Anahita; Garnier, Marc; Ferré, Alexis; Camous, Laurent; Heming, Nicholas; Lapidus, Nathanaël; Charles-Nelson, Anais; Mekontso-Dessap, Armand; Mercat, Alain; Asfar, Pierre; Beloncle, François; Demiselle, Julien; Pham, Tài; Pavot, Arthur; Monnet, Xavier; Richard, Christian; Demoule, Alexandre; Dres, Martin; Mayaux, Julien; Beurton, Alexandra; Daubin, Cédric; Descamps, Richard; Joret, Aurélie; Du Cheyron, Damien; Pene, Frédéric; Chiche, Jean-Daniel; Jozwiak, Mathieu; Jaubert, Paul; Fartoukh, Muriel; Teulier, Marion; Blayau, Clarisse; L’her, Erwen; Aubron, Cécile; Bodenes, Laetitia; Ferriere, Nicolas; Auchabie, Johann; Le Meur, Anthony; Pignal, Sylvain; Mazzoni, Thierry; Quenot, Jean-Pierre; Andreu, Pascal; Roudau, Jean-Baptiste; Labruyère, Marie; Nseir, Saad; Preau, Sébastien; Poissy, Julien; Mathieu, Daniel; Benhamida, Sarah; Paulet, Rémi; Roucaud, Nicolas; Thyrault, Martial; Daviet, Florence; Hraiech, Sami; Parzy, Gabriel; Sylvestre, Aude; Jochmans, Sébastien; Bouilland, Anne-Laure; Monchi, Mehran; Danguy Des Déserts, Marc; Mathais, Quentin; Rager, Gwendoline; Pasquier, Pierre; Reignier, Jean; Seguin, Amélie; Garret, Charlotte; Canet, Emmanuel; Dellamonica, Jean; Saccheri, Clément; Lombardi, Romain; Kouchit, Yanis; Jacquier, Sophie; Mathonnet, Armelle; Nay, Mai-Ahn; Runge, Isabelle; Martino, Frédéric; Flurin, Laure; Rolle, Amélie; Carles, Michel; Coudroy, Rémi; Thille, Arnaud; Frat, Jean-Pierre; Rodriguez, Maeva; Beuret, Pascal; Tientcheu, Audrey; Vincent, Arthur; Michelin, Florian; Tamion, Fabienne; Carpentier, Dorothée; Boyer, Déborah; Girault, Christophe; Gissot, Valérie; Ehrmann, Stéphan; Salmon Gandonniere, Charlotte; Elaroussi, Djlali; Delbove, Agathe; Fedun, Yannick; Huntzinger, Julien; Lebas, Eddy; Kisoka, Grâce; Grégoire, Céline; Marchetta, Stella; Lambermont, Bernard; Argaud, Laurent; Baudry, Thomas; Bertrand, Pierre-Jean; Dargent, Auguste; Guitton, Christophe; Chudeau, Nicolas; Landais, Mickaël; Darreau, Cédric; Gros, Antoine; Lacave, Guillaume; Bruneel, Fabrice; Neuville, Mathilde; Devaquet, Jérôme; Tachon, Guillaume; Gallot, Richard; Chelha, Riad; Galbois, Arnaud; Jallot, Anne; Chalumeau Lemoine, Ludivine; Kuteifan, Khaldoun; Pointurier, Valentin; Jandeaux, Louise-Marie; Mootien, Joy; Damoisel, Charles; Sztrymf, Benjamin; Schmidt, Matthieu; Combes, Alain; Chommeloux, Juliette; Luyt, Charles Edouard; Schortgen, Frédérique; Rusel, Leon; Jung, Camille; Gobert, Florent; Vimpere, Damien; Lamhaut, Lionel; Sauneuf, Bertrand; Charrrier, Liliane; Calus, Julien; Desmeules, Isabelle; Painvin, Benoît; Tadie, Jean-Marc; Castelain, Vincent; Michard, Baptiste; Herbrecht, Jean-Etienne; Baldacini, Mathieu; Weiss, Nicolas; Demeret, Sophie; Marois, Clémence; Rohaut, Benjamin; Moury, Pierre-Henri; Savida, Anne-Charlotte; Couadau, Emmanuel; Série, Mathieu; Alexandru, Nica; Bruel, Cédric; Fontaine, Candice; Garrigou, Sonia; Courtiade Mahler, Juliette; Leclerc, Maxime; Ramakers, Michel; Garçon, Pierre; Massou, Nicole; van Vong, Ly; Sen, Juliane; Lucas, Nolwenn; Chemouni, Franck; Stoclin, Annabelle; Avenel, Alexandre; Faure, Henri; Gentilhomme, Angélie; Ricome, Sylvie; Abraham, Paul; Monard, Céline; Textoris, Julien; Rimmele, Thomas; Montini, Florent; Lejour, Gabriel; Lazard, Thierry; Etienney, Isabelle; Kerroumi, Younes; Dupuis, Claire; Bereiziat, Marine; Coupez, Elisabeth; Thouy, François; Hofmann, Clément; Donat, Nicolas; Chrisment, Anne; Blot, Rose-Marie; Kimmoun, Antoine; Jacquot, Audrey; Mattei, Matthieu; Levy, Bruno; Ravan, Ramin; Dopeux, Loïc; Liteaudon, Jean-Mathias; Roux, Delphine; Rey, Brice; Anghel, Radu; Schenesse, Deborah; Gevrey, Vincent; Castanera, Jermy; Petua, Philippe; Madeux, Benjamin; Hartman, Otto; Piagnerelli, Michael; Joosten, Anne; Noel, Cinderella; Biston, Patrick; Noel, Thibaut; Bouar, Gurvan; Boukhanza, Messabi; Demarest, Elsa; Bajolet, Marie-France; Charrier, Nathanaël; Quenet, Audrey; Zylberfajn, Cécile; Dufour, Nicolas; Mégarbane, Bruno; Voicu, Sébastian; Deye, Nicolas; Malissin, Isabelle; Legay, François; Debarre, Matthieu; Barbarot, Nicolas; Fillatre, Pierre; Delord, Bertrand; Laterrade, Thomas; Saghi, Tahar; Pujol, Wilfried; Cungi, Pierre Julien; Esnault, Pierre; Cardinale, Mickael; Hong Tuan Ha, Vivien; Fleury, Grégory; Brou, Marie-Ange; Zafmahazo, Daniel; Tran-Van, David; Avargues, Patrick; Carenco, Lisa; Robin, Nicolas; Ouali, Alexandre; Houdou, Lucie; Le Terrier, Christophe; Suh, Noémie; Primmaz, Steve; Pugin, Jérome; Weiss, Emmanuel; Gauss, Tobias; Moyer, Jean-Denis; Burtz, Catherine Paugam; La Combe, Béatrice; Smonig, Rolland; Violleau, Jade; Cailliez, Pauline; Chelly, Jonathan; Marchalot, Antoine; Saladin, Cécile; Bigot, Christelle; Fayolle, Pierre-Marie; Fatséas, Jules; Ibrahim, Amr; Resiere, Dabor; Hage, Rabih; Cholet, Clémentine; Cantier, Marie; Trouiler, Pierre; Montravers, Philippe; Lortat-Jacob, Brice; Tanaka, Sebastien; Tran Dinh, Alexy; Duranteau, Jacques; Harrois, Anatole; Dubreuil, Guillaume; Werner, Marie; Godier, Anne; Hamada, Sophie; Zlotnik, Diane; Nougue, Hélène; Carteaux, Guillaume; de Prost, Nicolas; Mongardon, Nicolas; Lamraoui, Meriam; Alessandri, Claire; de Roux, Quentin; de Roquetaillade, Charles; Chousterman, Benjamin; Mebazaa, Alexandre; Gayat, Etienne; Pardo, Emmanuel; Satre-Buisson, Lea; Gutton, Christophe; Yvin, Elise; Marcault, Clémence; Azoulay, Elie; Darmon, Michael; Ait Oufella, Hafid; Hariri, Geofroy; Urbina, Tomas; Mazerand, Sandie; Santi, Francesca; Moine, Pierre; Annane, Djillali; Bouglé, Adrien; Omar, Edris; Lancelot, Aymeric; Begot, Emmanuelle; Plantefeve, Gaétan; Contou, Damien; Mentec, Hervé; Pajot, Olivier; Faguer, Stanislas; Cointault, Olivier; Lavayssiere, Laurence; Nogier, Marie-Béatrice; Jamme, Matthieu; Pichereau, Claire; Hayon, Jan; Outin, Hervé; Dépret, François; Coutrot, Maxime; Chaussard, Maité; Guillemet, Lucie; Gofn, Pierre; Thouny, Romain; Guntz, Julien; Jadot, Laurent; Persichini, Romain; Jean-Michel, Vanessa; Georges, Hugues; Caulier, Thomas; Pradel, Gaël; Hausermann, Marie-Hélène; Nguyen-Valat, Thi My Hue; Boudinaud, Michel; Vivier, Emmanuel; Rosseli, Sylvène; Bourdin, Gaël; Pommier, Christian; Vinclair, Marc; Poignant, Simon; Mons, Sandrine; Bougouin, Wulfran; Bruna, Franklin; Maestraggi, Quentin; Roth, Christian; Bitker, Laurent; Dhelft, François; Bonnet-Chateau, Justine; Filippelli, Mathilde; Morichau-Beauchant, Tristan; Thierry, Stéphane; Le Roy, Charlotte; Jouan, Mélanie Saint; Goncalves, Bruno; Mazeraud, Aurélien; Daniel, Matthieu; Sharshar, Tarek; Cadoz, Cyril; Gaci, Rostane; Gette, Sébastien; Louis, Guillaune; Sacleux, Sophie-Caroline; Ordan, Marie-Amélie; Cravoisy, Aurélie; Conrad, Marie; Courte, Guilhem; Gibot, Sébastien; Benzidi, Younès; Casella, Claudia; Serpin, Laurent; Setti, Jean-Lou; Besse, Marie-Catherine; Bourreau, Anna; Pillot, Jérôme; Rivera, Caroline; Vinclair, Camille; Robaux, Marie-Aline; Achino, Chloé; Delignette, Marie-Charlotte; Mazard, Tessa; Aubrun, Frédéric; Bouchet, Bruno; Frérou, Aurélien; Muller, Laura; Quentin, Charlotte; Degoul, Samuel; Stihle, Xavier; Sumian, Claude; Bergero, Nicoletta; Lanaspre, Bernard; Quintard, Hervé; Maiziere, Eve Marie; Egreteau, Pierre-Yves; Leloup, Guillaume; Berteau, Florin; Cottrel, Marjolaine; Bouteloup, Marie; Jeannot, Matthieu; Blanc, Quentin; Saison, Julien; Geneau, Isabelle; Grenot, Romaric; Ouchike, Abdel; Hazera, Pascal; Masse, Anne-Lyse; Demiri, Suela; Vezinet, Corinne; Baron, Elodie; Benchetrit, Deborah; Monsel, Antoine; Trebbia, Grégoire; Schaack, Emmanuelle; Lepecq, Raphaël; Bobet, Mathieu; Vinsonneau, Christophe; Dekeyser, Thibault; Delforge, Quentin; Rahmani, Imen; Vivet, Bérengère; Paillot, Jonathan; Hierle, Lucie; Chaignat, Claire; Valette, Sarah; Her, Benoït; Brunet, Jennifer; Page, Mathieu; Boiste, Fabienne; Collin, Anthony; Bavozet, Florent; Garin, Aude; Dlala, Mohamed; Mhamdi, Kais; Beilouny, Bassem; Lavalard, Alexandra; Perez, Severine; Veber, Benoit; Guitard, Pierre-Gildas; Gouin, Philippe; Lamacz, Anna; Plouvier, Fabienne; Delaborde, Bertrand; Kherchache, Aïssa; Chaalal, Amina; Ricard, Jean-Damien; Amouretti, Marc; Freita-Ramos, Santiago; Roux, Damien; Constantin, Jean-Michel; Assef, Mona; Lecore, Marine; Selves, Agathe; Prevost, Florian; Lamer, Christian; Shi, Ruiying; Knani, Lyes; Floury, Sébastien Pili; Vettoretti, Lucie; Levy, Michael; Marsac, Lucile; Dauger, Stéphane; Guilmin-Crépon, Sophie; Winiszewski, Hadrien; Piton, Gael; Soumagne, Thibaud; Capellier, Gilles; Putegnat, Jean-Baptiste; Bayle, Frédérique; Perrou, Maya; Thao, Ghyslaine; Géri, Guillaume; Charron, Cyril; Repessé, Xavier; Vieillard-Baron, Antoine; Guilbart, Mathieu; Roger, Pierre-Alexandre; Hinard, Sébastien; Macq, Pierre-Yves; Chaulier, Kevin; Goutte, Sylvie; Chillet, Patrick; Pitta, Anaïs; Darjent, Barbara; Bruneau, Amandine; Lasocki, Sigismond; Leger, Maxime; Gergaud, Soizic; Lemarie, Pierre; Terzi, Nicolas; Schwebel, Carole; Dartevel, Anaïs; Galerneau, Louis-Marie; Diehl, Jean-Luc; Hauw-Berlemont, Caroline; Péron, Nicolas; Guérot, Emmanuel; Amoli, Abolfazl Mohebbi; Benhamou, Michel; Deyme, Jean-Pierre; Andremont, Olivier; Lena, Diane; Cady, Julien; Causeret, Arnaud; de la Chapelle, Arnaud; Cracco, Christophe; Rouleau, Stéphane; Schnell, David; Foucault, Camille; Lory, Cécile; Chapelle, Thibault; Bruckert, Vincent; Garcia, Julie; Sahraoui, Abdlazize; Abbosh, Nathalie; Bornstain, Caroline; Pernet, Pierre; Poirson, Florent; Pasem, Ahmed; Karoubi, Philippe; Poupinel, Virginie; Gauthier, Caroline; Bouniol, François; Feuchere, Philippe; Heron, Anne; Carreira, Serge; Emery, Malo; Le Floch, Anne Sophie; Giovannangeli, Luana; Herzog, Nicolas; Giacardi, Christophe; Baudic, Thibaut; Thill, Chloé; Lebbah, Said; Palmyre, Jessica; Tubach, Florence; Hajage, David; Bonnet, Nicolas; Ebstein, Nathan; Gaudry, Stéphane; Cohen, Yves; Noublanche, Julie; Lesieur, Olivier; Sément, Arnaud; Roca-Cerezo, Isabel; Pascal, Michel; Sma, Nesrine; Colin, Gwenhaël; Lacherade, Jean-Claude; Bionz, Gauthier; Maquigneau, Natacha; Bouzat, Pierre; Durand, Michel; Hérault, Marie-Christine; Payen, Jean-Francois |
| Contributors: |
Institut Mondor de Recherche Biomédicale (IMRB); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) (CARMAS); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-CHU Henri Mondor Créteil; Hôpital Henri Mondor; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Centre d'Immunologie et des Maladies Infectieuses (CIMI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Centre de Recherche Saint-Antoine (CRSA); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); CHU Tenon AP-HP; Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF); Université de Lille-Centre National de la Recherche Scientifique (CNRS); Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire (GRC 29 - ARPE); Sorbonne Université (SU); Laboratoire de Mathématiques et de leurs Applications Pau (LMAP); Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS); CHU Pointe-à-Pitre / Abymes Guadeloupe; Infection et inflammation (2I); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM); Hôpital Raymond Poincaré AP-HP; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); CIC - HEGP (CIC 1418); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou APHP (HEGP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Hôpital Européen Georges Pompidou APHP (HEGP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO); CIC - CHU Henri Mondor; Centre Hospitalier Universitaire d'Angers (CHU Angers); Nouvel Hôpital Civil de Strasbourg; Hôpitaux Universitaires de Strasbourg (HUS); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Pôle des Cardiopathies Congénitales du Nouveau-Né à L'adulte - Centre Constitutif Cardiopathies Congénitales Complexes M3C, Groupe Hospitalier Paris Saint-Joseph, Hôpital Marie-Lannelongue, Inserm U999, Université Paris-Saclay; Hôpital Marie-Lannelongue-Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158); GIN Grenoble Institut des Neurosciences (GIN); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA); Université Grenoble Alpes (UGA) |
| Source: |
ISSN: 1364-8535. |
| Publisher Information: |
CCSD; BioMed Central |
| Publication Year: |
2024 |
| Collection: |
HAL e2s UPPA (Université de Pau et des Pays de l'Adour) |
| Subject Terms: |
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract; [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
International audience ; Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly related to Enterobacterales. Data regarding extended-spectrum beta-lactamase producing Enterobacterales (ESBL-E) VAP are scarce. We aimed to investigate risk factors and outcomes of ESBL-E related VAP among critically ill coronavirus infectious disease-19 (COVID-19) patients who developed Enterobacterales related VAP.Patients and methods: We performed an ancillary analysis of a multicenter prospective international cohort study (COVID-ICU) that included 4929 COVID-19 critically ill patients. For the present analysis, only patients with complete data regarding resistance status of the first episode of Enterobacterales related VAP (ESBL-E and/or carbapenem-resistant Enterobacterales, CRE) and outcome were included.Results We included 591 patients with Enterobacterales related VAP. The main causative species were Enterobacter sp (n = 224) , E. coli (n = 111) and K. pneumoniae (n = 104). One hundred and fifteen patients (19%), developed a first ESBL-E related VAP, mostly related to Enterobacter sp (n = 40), K. pneumoniae (n = 36), and E. coli (n = 31). Eight patients (1%) developed CRE related VAP. In a multivariable analysis, African origin (North Africa or Sub-Saharan Africa) (OR 1.7 [1.07–2.71], p = 0.02), time between intubation and VAP (OR 1.06 [1.02–1.09], p = 0.002), PaO 2 /FiO 2 ratio on the day of VAP (OR 0.997 [0.994–0.999], p = 0.04) and trimethoprim-sulfamethoxazole exposure (OR 3.77 [1.15–12.4], p = 0.03) were associated with ESBL-E related VAP. Weaning from mechanical ventilation and mortality did not significantly differ between ESBL-E and non ESBL-E VAP. Conclusion ESBL-related VAP in COVID-19 critically-ill patients was not infrequent. Several risk factors were identified, among which some are modifiable and deserve further investigation. There was no impact of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s13054-024-04906-2 |
| Availability: |
https://hal.science/hal-04820262; https://hal.science/hal-04820262v1/document; https://hal.science/hal-04820262v1/file/Ventilator-associated%20pneumonia%20related%20to%20extended-spectrum%20beta-lactamase%20producing%20Enterobacterales%20during%20severe%20acute%20respiratory%20syndrome%20coronavirus%202%20infection%20risk%20factors%20and%20prognosis.pdf; https://doi.org/10.1186/s13054-024-04906-2 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.8F50D7AF |
| Database: |
BASE |