| Title: |
Quality of life and multiple long-term conditions in Southeast Asia: a systematic review and meta-analysis |
| Authors: |
Ikhile, D; Highton, P; Gillies, C; Abdala, R; Ardavani, A; Arora, M; Banstola, A; Brahmbhatt, A; Cassambai, S; Funnell, MP; Goenka, S; Jeffers, S; Kondal, D; Mohan, S; Mulakalapalli, P; Oli, N; Peace, A; Singh, K; Vaidya, A; Venkateshmurthy, NS; Prabhakaran, D; Khunti, K |
| Contributors: |
Ikhile, Deborah 0000-0002-4343-1674; Highton, Patrick 0000-0002-0410-5788; Ardavani, Ashkon 0000-0002-9442-3295; Arora, Monika 0000-0001-9987-3933; Banstola, Amrit 0000-0003-3185-9638; Cassambai, Shabana 0000-0001-6201-9063; Funnell, Mark P. 0000-0001-7473-5999; Goenka, Shifalika 0000-0001-6993-2883; Jeffers, Shavez 0000-0001-7542-1772; Mulakalapalli, Prakash 0009-0000-9303-4741; Peace, Arron 0009-0005-3859-2907; Singh, Kuldeep 0000-0002-9375-3233; Venkateshmurthy, Nikhil Srinivasapura 0000-0003-4037-6371; Prabhakaran, Dorairaj 0000-0002-3172-834X |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2025 |
| Collection: |
Brunel University London: Brunel University Research Archive (BURA) |
| Subject Terms: |
outcomes research; quality of life |
| Description: |
Data availability: The data informing from this review are extracted from previously published studies in the public domain. The dataset generated and analysed during the review is available on Figshare repository (https://doi.org/10.25392/leicester.data.30156316.v1). ; "We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply." ; Supplementary information is available online at: https://www.nature.com/articles/s41467-025-68197-z#Sec16 . ; This review systematically synthesised the evidence on quality of life measures and outcomes for people living with multiple long-term conditions in the Southeast Asia region. Results were analysed using a combination of methods, meta-analysis for studies where the same quality of life score was reported across three or more cohorts, and descriptive narrative synthesis. In total, 34 studies comprising 11,876 participants were included in the narrative synthesis and 14 of these were included in meta-analysis. The most common quality of life tools used included WHOQOL-BREF ( n = 8) and EQ-5D-5L ( n = 3) with pooled mean values of 70.47 (95% CI: 62.71 to 78.24) and 0.76 (95% CI: 0.67 to 0.84) respectively, indicating reduced but good quality of life. As healthcare systems adapt to the evolving challenges associated with multiple long-term conditions, understanding the tools and measures used to assess quality of life in different contexts becomes imperative to account for disease combinations and cultural nuances. ; This research was funded by the NIHR Global Health Research Centre for Multiple Long-Term Conditions using UK aid from the UK Government to support global health research (NIHR203257). The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the UK government. K.K. is supported by the National Institute for Health ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
1–9; Electronic |
| Language: |
English |
| Relation: |
Nature Communications; https://bura.brunel.ac.uk/handle/2438/32757; 1461 |
| DOI: |
10.1038/s41467-025-68197-z |
| Availability: |
https://bura.brunel.ac.uk/handle/2438/32757; https://doi.org/10.1038/s41467-025-68197-z |
| Rights: |
Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ ; https://creativecommons.org/licenses/by/4.0/legalcode.en ; The Author(s) |
| Accession Number: |
edsbas.8F68C943 |
| Database: |
BASE |