| Title: |
Cognitive and psychiatric symptom trajectories 2-3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK |
| Authors: |
Taquet, M; Skorniewska, Z; De Deyn, T; Hampshire, A; Trender, WR; Hellyer, PJ; Chalmers, JD; Ho, L-P; Horsley, A; Marks, M; Poinasamy, K; Raman, B; Leavy, OC; Richardson, M; Elneima, O; McAuley, HJC; Shikotra, A; Singapuri, A; Sereno, M; Saunders, RM; Harris, VC; Rogers, N; Houchen-Wolloff, L; Greening, NJ; Mansoori, P; Harrison, EM; Docherty, AB; Lone, NI; Quint, J; Brightling, CE; Wain, LV; Evans, RA; Geddes, JR; Harrison, PJ |
| Contributors: |
Group, PHOSP-COVID Study Collaborative |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background COVID-19 is known to be associated with increased risks of cognitive and psychiatric outcomes after the acute phase of disease. We aimed to assess whether these symptoms can emerge or persist more than 1 year after hospitalisation for COVID-19, to identify which early aspects of COVID-19 illness predict longer-term symptoms, and to establish how these symptoms relate to occupational functioning. Methods The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study of adults (aged ≥18 years) who were hospitalised with a clinical diagnosis of COVID-19 at participating National Health Service hospitals across the UK. In the C-Fog study, a subset of PHOSP-COVID participants who consented to be recontacted for other research were invited to complete a computerised cognitive assessment and clinical scales between 2 years and 3 years after hospital admission. Participants completed eight cognitive tasks, covering eight cognitive domains, from the Cognitron battery, in addition to the 9-item Patient Health Questionnaire for depression, the Generalised Anxiety Disorder 7-item scale, the Functional Assessment of Chronic Illness Therapy Fatigue Scale, and the 20-item Cognitive Change Index (CCI-20) questionnaire to assess subjective cognitive decline. We evaluated how the absolute risks of symptoms evolved between follow-ups at 6 months, 12 months, and 2–3 years, and whether symptoms at 2–3 years were predicted by earlier aspects of COVID-19 illness. Participants completed an occupation change questionnaire to establish whether their occupation or working status had changed and, if so, why. We assessed which symptoms at 2–3 years were associated with occupation change. People with lived experience were involved in the study. Findings 2469 PHOSP-COVID participants were invited to participate in the C-Fog study, and 475 participants (191 [40·2%] females and 284 [59·8%] males; mean age 58·26 [SD 11·13] years) who were discharged from one of 83 hospitals provided data at the ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1016/s2215-0366(24)00214-1 |
| Availability: |
https://doi.org/10.1016/s2215-0366(24)00214-1; https://ora.ox.ac.uk/objects/uuid:9dff5356-14e2-413e-8598-10f83247d7e0 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.8F6FC15 |
| Database: |
BASE |