| Title: |
Non-Anticoagulation Strategies Aimed at Primary Stroke Prevention in Nascent Atrial Fibrillation. |
| Authors: |
Sgarra L; Desantis V; Matteucci A; Caccavo VP; Troisi F; Di Monaco A; Mangini F; Katsouras G; Guaricci AI; Dadamo ML; Fortunato F; Nacci C; Potenza MA; Montagnani M; Grimaldi M. |
| Contributors: |
Sgarra, L; Desantis, V; Matteucci, A; Caccavo, Vp; Troisi, F; Di Monaco, A; Mangini, F; Katsouras, G; Guaricci, Ai; Dadamo, Ml; Fortunato, F; Nacci, C; Potenza, Ma; Montagnani, M; Grimaldi, M. |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| Subject Terms: |
stroke; atrial fibrillation; preventive therapy |
| Description: |
At its earliest appearance, atrial fibrillation (AF) is often unnoticed, asymptomatic, and/or merely device-detected. Widespread use of heart-rate monitoring technologies has facilitated such “nascent atrial fibrillation (nAF)” recognition. Consequently, clinicians face a growing number of patients affected by new-onset AF in the absence of a definite indication for anticoagulation due to several counterarguments: (1) a CHA2DS2-VA score ≤ 1 in otherwise apparently healthy subjects; (2) an uncertain embolic/hemorrhagic benefit/risk ratio with anticoagulation; (3) EKG demonstration and confirmation of AF; and (4) existence of a pathogenic mechanism other than atrial hypercoagulability. In this frustrating limitation of pharmacological options, cardiologists may miss a complete comprehension of drugs with proven anti-ictal potential, whose administration may serve both as a bridge strategy toward future anticoagulation and as a consolidative strategy paralleling anticoagulation. This review aims to summarize and elucidate such therapeutic strategies and their preventative mechanisms. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40149635; info:eu-repo/semantics/altIdentifier/wos/WOS:001452905900001; volume:13; issue:3; firstpage:1; lastpage:30; numberofpages:30; journal:BIOMEDICINES; https://hdl.handle.net/11586/533600 |
| DOI: |
10.3390/biomedicines13030660 |
| Availability: |
https://hdl.handle.net/11586/533600; https://doi.org/10.3390/biomedicines13030660 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.8F77AD7D |
| Database: |
BASE |