Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose
| Title: | Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose |
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| Authors: | Renia, L; Goh, YS; Rouers, A; Le Bert, N; Chia, WN; Chavatte, JM; Fong, S‐; Chang, ZW; Zhuo, NZ; Tay, MZ; Chan, YH; Tan, CW; Yeo, NK; Amrun, SN; Huang, Y; Wong, JXE; Hor, PX; Loh, CY; Wang, B; Ngoh, EZX; Salleh, SNM; Carissimo, G; Dowla, S; Lim, AJ; Zhang, J; Lim, JME; Wang, CI; Ding, Y; Pada, S; Sun, LJ; Somani, J; Lee, ES; Ong, DLS; Ruesta, AT; Neo, V; Chen, WY; Goh, EYW; Ong, ASM; Chua, ACY; Nguee, SYT; Tan, YJ; Tang, W; Leo, Y‐; MacAry, PA; Lin, RTP; Wang, LF; Ren, EC; Lye, DC; Bertoletti, A; Young, BE; Ng, LFP |
| Publisher Information: | Springer Science and Business Media LLC |
| Publication Year: | 2022 |
| Collection: | The University of Liverpool Repository |
| Description: | Understanding the impact of age on vaccinations is essential for the design and delivery of vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of multiple compartments of the memory immune response in 312 individuals vaccinated with the BNT162b2 SARS-CoV-2 mRNA vaccine. Two vaccine doses induce high antibody and T cell responses in most individuals. However, antibody recognition of the Spike protein of the Delta and Omicron variants is less efficient than that of the ancestral Wuhan strain. Age-stratified analyses identify a group of low antibody responders where individuals ≥60 years are overrepresented. Waning of the antibody and cellular responses is observed in 30% of the vaccinees after 6 months. However, age does not influence the waning of these responses. Taken together, while individuals ≥60 years old take longer to acquire vaccine-induced immunity, they develop more sustained acquired immunity at 6 months post-vaccination. A third dose strongly boosts the low antibody responses in the older individuals against the ancestral Wuhan strain, Delta and Omicron variants. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 2041-1723 |
| Relation: | Collapse authors list. Renia, L, Goh, YS, Rouers, A orcid:0000-0002-8437-3204 , Le Bert, N orcid:0000-0003-0502-2527 , Chia, WN orcid:0000-0001-7287-694X , Chavatte, JM orcid:0000-0002-0003-541X , Fong, S‐, Chang, ZW, Zhuo, NZ orcid:0000-0002-7692-8265 , Tay, MZ orcid:0000-0002-1763-913X et al (show 41 more authors) , Chan, YH, Tan, CW, Yeo, NK orcid:0000-0002-8294-1474 , Amrun, SN, Huang, Y, Wong, JXE, Hor, PX, Loh, CY, Wang, B orcid:0000-0002-3112-7341 , Ngoh, EZX orcid:0000-0001-5407-0280 , Salleh, SNM orcid:0000-0002-6110-7472 , Carissimo, G orcid:0000-0002-9703-9096 , Dowla, S, Lim, AJ, Zhang, J, Lim, JME, Wang, CI orcid:0000-0001-9170-2996 , Ding, Y, Pada, S, Sun, LJ, Somani, J, Lee, ES orcid:0000-0003-4963-535X , Ong, DLS, Ruesta, AT, Neo, V, Chen, WY, Goh, EYW, Ong, ASM, Chua, ACY, Nguee, SYT, Tan, YJ, Tang, W, Leo, Y‐ orcid:0000-0003-4978-5825 , MacAry, PA, Lin, RTP orcid:0000-0001-6654-026X , Wang, LF orcid:0000-0003-2752-0535 , Ren, EC, Lye, DC, Bertoletti, A, Young, BE orcid:0000-0003-1010-2230 and Ng, LFP orcid:0000-0003-4071-5222 (2022) Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose Nature Communications, 13 (1). 4615-. ISSN 2041-1723, 2041-1723 |
| DOI: | 10.1038/s41467-022-32312-1 |
| Availability: | https://livrepository.liverpool.ac.uk/3165585/; https://doi.org/10.1038/s41467-022-32312-1 |
| Accession Number: | edsbas.9002DA20 |
| Database: | BASE |