| Title: |
The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark): study design and population |
| Authors: |
Calandra Buonaura G.; Sambati L.; Baschieri F.; Vitiello M.; Contin M.; Tonon C.; Capellari S.; Provini F.; Cortelli P.; Barletta G.; Caltabiano G.; Cecere A.; Gallassi R.; Giannini G.; Guaraldi P.; Lodi R.; Lopane G.; Manners D. N.; Martinelli P.; Miele F.; Mignani F.; Mohamed S.; Nassetti S.; Oppi F.; Parchi P.; Pierangeli G.; Poda R.; Scaglione C.; Solieri L.; Stanzani Maserati M.; Testa C. |
| Contributors: |
Calandra Buonaura G.; Sambati L.; Baschieri F.; Vitiello M.; Contin M.; Tonon C.; Capellari S.; Provini F.; Cortelli P.; Barletta G.; Caltabiano G.; Cecere A.; Gallassi R.; Giannini G.; Guaraldi P.; Lodi R.; Lopane G.; Manners D.N.; Martinelli P.; Miele F.; Mignani F.; Mohamed S.; Nassetti S.; Oppi F.; Parchi P.; Pierangeli G.; Poda R.; Scaglione C.; Solieri L.; Stanzani Maserati M.; Testa C. |
| Publication Year: |
2020 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
Atypical parkinsonism; Cohort study; Motor symptom; Non-motor symptom; Parkinson’s disease; Study design |
| Description: |
Objective: The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark) was designed to prospectively characterize motor and non-motor features in patients with a progressive neurodegenerative disease starting with parkinsonism since early disease stage and to investigate their diagnostic and prognostic role in the differential diagnosis of Parkinson’s disease from atypical parkinsonisms. The aim of this paper is to describe the method and population of the BoProPark study. Methods: Patients referred to our Department with parkinsonism within 3years from motor onset were recruited. Secondary causes of parkinsonism were excluded. Each patient underwent a comprehensive evaluation of motor and non-motor symptoms, assessed by means of quantitative, objective instrumental tests in addition to scales and questionnaires. The evaluations were performed at enrolment (T0), after 16months (T1) and after 5years (T2). Diagnoses were made according to consensus criteria. Results: We recruited 150 patients, with mean age 61.5 ± 9.8years and mean disease duration 20 ± 9months. H&Y stage was 1 in 47.3% and 2 in 46.7% of cases. Mean UPDRS-III was 17.7 ± 9.2. Fifty-four patients were on dopaminergic treatment with median levodopa equivalent daily dose (LEDD) of 200mg. Conclusions: We expect that the prospective nature of the BoProPark study as well as the comprehensive, instrumental evaluation of motor and non-motor symptoms in patients with parkinsonism will provide important new insights for both clinical practice and research. Our data could be used for comparison with other cohorts and shared with national and international collaborators to develop new innovative projects. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32219591; info:eu-repo/semantics/altIdentifier/wos/WOS:000521890600003; volume:41; firstpage:2531; lastpage:2537; numberofpages:7; journal:NEUROLOGICAL SCIENCES; http://hdl.handle.net/11585/780404 |
| DOI: |
10.1007/s10072-020-04305-9 |
| Availability: |
http://hdl.handle.net/11585/780404; https://doi.org/10.1007/s10072-020-04305-9; https://link.springer.com/article/10.1007/s10072-020-04305-9 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.9016BB10 |
| Database: |
BASE |