| Title: |
Cognitive trajectories and incident dementia after a cardiovascular event in older adults |
| Authors: |
Vishwanath, Swarna; Hopper, Ingrid; Wolfe, Rory; Polekhina, Galina; Reid, Christopher M.; Tonkin, Andrew M.; Murray, Anne M.; Shah, Raj C.; Storey, Elsdon; Woods, Robyn L.; McNeil, John; Orchard, Suzanne G.; Nelson, Mark R.; Steves, Claire J.; Ryan, Joanne |
| Contributors: |
National Institutes of Health |
| Source: |
Alzheimer's & Dementia ; volume 19, issue 8, page 3670-3678 ; ISSN 1552-5260 1552-5279 |
| Publisher Information: |
Wiley |
| Publication Year: |
2023 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
INTRODUCTION Cardiovascular disease (CVD) is a recognized risk factor for dementia. Here we determined the extent to which an incident CVD event modifies the trajectory of cognitive function and risk of dementia. METHODS 19,114 adults (65+) without CVD or dementia were followed prospectively over 9 years. Incident CVD (fatal coronary heart disease, nonfatal myocardial infarction [MI], stroke, hospitalization for heart failure) and dementia ( Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) were adjudicated by experts. RESULTS Nine hundred twenty‐two participants had incident CVD, and 44 developed dementia after CVD (4.9% vs. 4.4% for participants without CVD). Following a CVD event there was a short‐term drop in processing speed (−1.97, 95% confidence interval [CI]: −2.57 to −1.41), but there was no significant association with longer‐term processing speed. In contrast, faster declines in trajectories of global function (−0.56, 95% CI: −0.76 to −0.36), episodic memory (−0.10, 95% CI: −0.16 to −0.04), and verbal fluency (−0.19, 95% CI: −0.30 to −0.01) were observed. DISCUSSION Findings highlight the importance of monitoring cognition after a CVD event. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/alz.13006 |
| Availability: |
https://doi.org/10.1002/alz.13006; https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.13006; https://onlinelibrary.wiley.com/doi/full-xml/10.1002/alz.13006 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.90EDE636 |
| Database: |
BASE |