| Title: |
Multisystem inflammatory syndrome in children (MIS-C) possibly secondary to COVID-19 mRNA vaccination |
| Authors: |
Wangu, Zoon; Swartz, Hannah; Doherty, Meaghan |
| Contributors: |
T.H. Chan School of Medicine; Department of Pediatrics, Division of Pediatric Cardiology; Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology |
| Source: |
BMJ case reports ; 15 ; 3 ; e247176 |
| Publication Year: |
2022 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
COVID-19; Pediatrics; Vaccination; Immunization; Immunology and Infectious Disease; Infectious Disease; Pathological Conditions; Signs and Symptoms; Therapeutics; Virus Diseases |
| Description: |
Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 is a postinfectious condition identified during the COVID-19 pandemic with specific Centers for Disease Control and Prevention and WHO criteria. Theoretical concerns have been raised whether MIS-C might also occur after COVID-19 vaccination, as the pathogenesis of MIS-C is not yet entirely understood. We present a woman in her late teens who developed MIS-C after having received two doses of Pfizer BioNTech COVID-19 vaccine 12 weeks prior, in the setting of documented anti-spike SARS-CoV-2 IgG positive, antinucleocapsid SARS-CoV-2 IgG negative, and multiple negative surveillance SARS-CoV-2 PCRs done in the 12-week period prior to development of MIS-C. While vaccination remains safe and critical in controlling the pandemic, it may be considered as a potential trigger for MIS-C in patients with no history of infection. Further surveillance is necessary to determine whether MIS-C will emerge as a confirmed adverse event after COVID-19 vaccination. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
29327229 |
| Relation: |
Link to Article in PubMed; http://hdl.handle.net/20.500.14038/27653; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1398&context=covid19&unstamped=1; https://escholarship.umassmed.edu/covid19/390; covid19/390 |
| DOI: |
10.1136/bcr-2021-247176 |
| Availability: |
https://doi.org/10.1136/bcr-2021-247176; https://hdl.handle.net/20.500.14038/27653; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1398&context=covid19&unstamped=1; https://escholarship.umassmed.edu/covid19/390 |
| Rights: |
Copyright © BMJ Publishing Group Limited 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. ; http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.912174EB |
| Database: |
BASE |