| Title: |
Change of CRP and D-dimer Level of COVID-19 Patients: An Observational Prospective Study |
| Authors: |
Saha, Nihar Ranjan; Islam, Md Sayedul; Razzaque, SM Abdur; Biswas, Bipul Kanti; Dey, Pulak Kumar; Hossain, Md Delwar; Sarkar, Nirmal Kanti; Kar, Sanjoy Kumar; Gain, Subrata Kumar; Rashid, HM Aminur; Podder, Palash Kumar; Chowdhury, Romal |
| Source: |
Chest & Heart Journal ; Vol. 45 No. 1 (2021); 19-25 ; 1562-5044 |
| Publisher Information: |
The Chest and Heart Association of Bangladesh |
| Publication Year: |
2023 |
| Collection: |
Bangladesh Journals Online (BanglaJOL) |
| Subject Terms: |
COVID-19; CRP and D-dimer |
| Time: |
Bangladesh |
| Description: |
Background: COVID-19 is a global pandemic causing million of death during last two years, so it became a global health and economic burden right now. COVID-19 is a Novel infectious disease, for which there is no definite curable treatment till now. It is therefore necessary to explore biomarkers to determine the extent of lung lesions and disease severity. CRP levels are elevated in patients with COVID-19 and may be different with severity of the disease. Elevated plasma Ddimer is a hallmark to determine cardiovascular complications related to patients. Objective: The primary objective of the present study was to evaluate the changes of CRP and D-dimer level of COVID-19 patients in respect to severity of the disease. Methods: This prospective observational study was conducted in Private set up and OPD, National Institute of Diseases of the Chest & Hospital, Mohakhali, Dhaka, between January 2020 to July 2020. A total of 49 patients with COVID-19 were included in the study. Diagnosed case of RT-PCR positive patients with or without respiratory symptoms were assessed by CRP and D-dimer level on the first visit. After 7 days CRP and D-dimer levels were collected to compare with baseline levels. All other clinical, laboratory, and outcome data were documented using a standardized data collection form. Results: In this study 49 patients with COVID-19, majority 22(44.9%) patients belonged to age 41 to 60 years. The mean age was 53.3±14.7 years. Male patients were predominant 41(83.7%) with male female ratio was 5.1:1. More than one third 17(34.7%) patients had hypertension followed by 15(30.6%) had diabetes mellitus, 4(8.2%) had COPD, 3(6.1%) had asthma and 2(4.1%) had CKD. Co-morbidity was significantly higher in respiratory symptoms than without respiratory symptoms. CRP level was significantly reduced after 7 days compared with baseline (10.1±13.0 mg/L vs39.6±54.6 mg/L). Twenty three (46.9%) patients were found D-dimer >3.0 gm/dl in baseline and 14(28.6%) in after 7 days, that was not significant (p=0.066). ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://banglajol.info/index.php/CHJ/article/view/64722/44043; https://banglajol.info/index.php/CHJ/article/view/64722 |
| Availability: |
https://banglajol.info/index.php/CHJ/article/view/64722 |
| Rights: |
Copyright (c) 2021 Chest & Heart Journal ; https://creativecommons.org/licenses/by-nc/4.0 |
| Accession Number: |
edsbas.91457838 |
| Database: |
BASE |