| Title: |
Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S) |
| Authors: |
Pedersen, T R; Olsson, A G; Faergeman, O; Kjekshus, J; Wedel, H; Berg, K; Wilhelmsen, L; Haghfelt, T; Thorgeirsson, G; Pyörälä, K; Miettinen, T; Christophersen, B; Tobert, J A; Musliner, T A; Cook, T J |
| Contributors: |
Aker Hospital, Oslo, Norway. |
| Publisher Information: |
Lippincott Williams & Wilkins |
| Publication Year: |
2010 |
| Collection: |
Hirsla - Landspítali University Hospital research archive |
| Subject Terms: |
Adult; Aged; Anticholesteremic Agents; Cholesterol; Dietary; Coronary Disease; Double-Blind Method; Female; Follow-Up Studies; Humans; Incidence; Lipoproteins; Male; Middle Aged; Myocardial Infarction; Predictive Value of Tests; Regression Analysis; Risk Factors; Sensitivity and Specificity; Simvastatin; Triglycerides |
| Description: |
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field ; BACKGROUND: The Scandinavian Simvastatin Survival Study (4S) randomized 4444 patients with coronary heart disease (CHD) and serum cholesterol 5.5 to 8.0 mmol/L (213 to 310 mg/dL) with triglycerides < or =2.5 mmol/L (220 mg/dL) to simvastatin 20 to 40 mg or placebo once daily. Over the median follow-up period of 5.4 years, one or more major coronary events (MCEs) occurred in 622 (28%) of the 2223 patients in the placebo group and 431 (19%) of the 2221 patients in the simvastatin group (34% risk reduction, P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0009-7322 |
| Relation: |
http://circ.ahajournals.org/cgi/content/abstract/97/15/1453; Circulation. 1998, 97(15):1453-60; 9576425; http://hdl.handle.net/2336/108545; Circulation |
| Availability: |
http://hdl.handle.net/2336/108545 |
| Accession Number: |
edsbas.91530109 |
| Database: |
BASE |