| Title: |
Impact of vaccine schedule change on pertussis epidemiology in France: a modelling and serological study |
| Authors: |
Paireau, Juliette; Guillot, Sophie; Aït El Belghiti, Fatima; Matczak, Soraya; Trombert-Paolantoni, Sabine; Jacomo, Véronique; Taha, Muhamed-Kheir; Salje, Henrik; Brisse, Sylvain; Lévy-Bruhl, Daniel; Cauchemez, Simon; Toubiana, Julie |
| Contributors: |
Direction des maladies infectieuses - Infectious Diseases Division Saint-Maurice; Santé publique France - French National Public Health Agency Saint-Maurice, France; Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases; Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens; Institut Pasteur Paris (IP)-Université Paris Cité (UPCité); Centre national de Référence de la Coqueluche et autres Bordetelloses - National Reference Center for Whooping Cough and other Bordetella infections (CNR); Infections respiratoires et vaccination Saint-Maurice; Département de Pédiatrie et maladies infectieuses CHU Necker; Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Laboratoire CERBA Saint Ouen l'Aumône; Eurofins Biomnis; Infections Bactériennes Invasives - Invasive Bacterial Infections; Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR); University of Cambridge Cambridge, UK (CAM); This project was funded by the INCEPTION interdisciplinary project at Institut Pasteur, Understanding whooping cough resurgence in Europe by combining genomic, epidemiological, and sociological approaches (French Government Investissements d'Avenir grant ANR-16-CONV-0005). This work also received financial support from the French Government's Investissement d'Avenir programme, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases (grant n_ANR-10-LABX-62-IBEID). Institutional support was provided by an Institut Pasteur and Santé publique France grant to SB. SM was supported by a PhD grant from Fondation pour la Recherche Médicale. We thank Martin Chalumeau (CRESS, INSERM, Paris, France), for his contributions to the serological study.; ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016); ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010) |
| Source: |
ISSN: 1473-3099. |
| Publisher Information: |
CCSD; Elsevier Science; The Lancet Pub. Group, 2001- |
| Publication Year: |
2022 |
| Subject Terms: |
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; [STAT]Statistics [stat] |
| Description: |
Le titre de la version publiée est : "Effect of change in vaccine schedule on pertussis epidemiology in France: a modelling and serological study". ; International audience ; Background: In 2013, France modified its pertussis vaccination schedule to remove one dose at 3 months of age and change the age of the booster dose from 16 to 11 months. We aimed to assess the subsequent impact on pertussis epidemiology in France. Methods: We analysed the PCR test results of nasopharyngeal swabs (N=7493) collected from symptomatic outpatients aged 2-20 years old between 2012 and 2019 in France. We developed a negative binomial regression model for the number of pertussis cases by year and age. The linear predictor included the year, the age group, the population size and a proxy of waning immunity that could vary with vaccine schedule. We also compared the anti-pertussis toxin (PT) antibody levels of 315 children born before and after the vaccine schedule change. Findings: The model that best fitted the 2012-2018 epidemiological data supported a faster waning of immunity following vaccination with the new vaccine schedule. Three years after vaccination, the risk of developing pertussis was 1.7 (95% CI, 1.4-2.0) times higher for children vaccinated according to the new schedule than those vaccinated according to the previous schedule. The model correctly predicted the age distribution of cases in 2019. Anti-PT IgG levels were significantly lower in children born after implementation of the new schedule, compared to children born before. Interpretation: A shorter-lived protection induced by the 2/4+11 vaccine schedule recommended in France since 2013 is associated with an increase of pertussis cases in 2-5-year olds. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34672963; PUBMED: 34672963 |
| DOI: |
10.1016/S1473-3099(21)00267-X |
| Availability: |
https://pasteur.hal.science/pasteur-03694021; https://pasteur.hal.science/pasteur-03694021v1/document; https://pasteur.hal.science/pasteur-03694021v1/file/Paireau_pertussis_2021.pdf; https://doi.org/10.1016/S1473-3099(21)00267-X |
| Rights: |
http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.91AD4680 |
| Database: |
BASE |