| Title: |
Primary Resistance to ALK Inhibitors in a Patient with Nonsmall Cell Lung Cancer with ALK Rearrangement: A Case Report with Review of Literature |
| Authors: |
Devaraj, Suma; Panda, Soumya Surath; Arun, Gourab; Panda, Adya Kinkar; Mohapatra, Debahuti; Moharana, Lalatendu; Kolluri, Spoorthy; Kilaru, Sindhu; Mohanty, Swati Sucharita; Biswas, Ghanashyam |
| Source: |
Indian Journal of Medical and Paediatric Oncology ; ISSN 0971-5851 0975-2129 |
| Publisher Information: |
Georg Thieme Verlag KG |
| Publication Year: |
2023 |
| Description: |
Anaplastic lymphoma kinase inhibitors (ALKi) are the standard of care for metastatic ALK-rearranged nonsmall cell lung cancer (NSCLC). Though most patients respond well to ALK, seldom there are instances where the disease progresses rapidly. Here, we present a case of a 41-years-old male diagnosed as NSCLC with ALK rearrangement. Despite being started on first- and second-generation ALK-targeted therapy, he had rapid disease progression ultimately succumbing to the disease within 3 months of diagnosis. We suspect that our patient has a variant of ALK, making him resistant to both first- and second-line targeted therapy. Subjecting such nonresponders to next-generation sequencing and identifying the variants might help to recognize a subset of patients among ALK+ NSCLC who will need intense monitoring and early institution of other therapies for a better outcome. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1055/s-0043-1776704 |
| DOI: |
10.1055/s-0043-1776704.pdf |
| Availability: |
https://doi.org/10.1055/s-0043-1776704; http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-1776704.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.91B93306 |
| Database: |
BASE |