| Title: |
A characterization of the HIV population with limited/exhausted treatment options: a multicenter Belgian study. |
| Authors: |
Nasreddine, Rakan; Darcis, Gilles; Yombi, Jean Cyr; De Munter, Paul; Florence, Eric; Van Praet, Jens; Demeester, Rémy; Allard, Sabine D; Schroeder, Melanie; Dusabineza, Ange-Clarisse; Delforge, Marc; De Wit, Stéphane |
| Source: |
Acta Clinica Belgica, 79 (3), 153 - 159 (2024-06) |
| Publisher Information: |
Taylor and Francis Ltd. |
| Publication Year: |
2024 |
| Collection: |
University of Liège: ORBi (Open Repository and Bibliography) |
| Subject Terms: |
Belgium; HIV; extensive treatment history; limited/exhausted treatment options; multi-drug resistant HIV-1; Anti-HIV Agents; Humans; Belgium/epidemiology; Female; Male; Cross-Sectional Studies; Middle Aged; Adult; Anti-HIV Agents/therapeutic use; HIV-1; Prevalence; CD4 Lymphocyte Count; HIV Infections/drug therapy; HIV Infections/epidemiology; Viral Load; HIV Infections; Medicine (all); Human health sciences; Immunology & infectious disease; Sciences de la santé humaine; Immunologie & maladie infectieuse |
| Description: |
peer reviewed ; [en] OBJECTIVE: Describe the prevalence and characteristics of people living with HIV (PLWH) in Belgium with limited/exhausted treatment options. METHODS: A cross-sectional, multicenter study involving adult treatment-experienced individuals with limited/exhausted treatment options defined as having a multi-drug resistant HIV-1 or a history of multiple treatment changes. The primary outcome was to determine the prevalence of these individuals and classify them based on their two most recent consecutive HIV-1 viral loads (VLs): suppressed (2 VLs < 50 copies/mL), intermediate (≥1 VL between 50-200 copies/mL), or unsuppressed (2 VLs > 200 copies/mL). Secondary outcome was to characterize the participants included in this analysis. RESULTS: There were 119 individuals included (prevalence of 0.97%; 119 of 12 282 in care). The majority were aged > 50 years (88.2%), women represented 35.3%, and individuals were primarily White (54.7%). Median (IQR) CD4+ T-cell count was 635 (400-875) cells/µL and most (42%) were on a 3-drug ART regimen. Overall, 87.4% were classified as suppressed, 9.2% as intermediate, and 3.4% as unsuppressed. On multivariable analysis, CD4+ T-cell count < 200 cells/µL was associated with being classified as intermediate or unsuppressed (p = 0.004). CONCLUSION: In this analysis of PLWH in Belgium, individuals with limited/exhausted treatment options represented a small fraction. Most were on a 3-drug ART regimen, were virologically suppressed, and had a CD4+ T-cell count within normal range. A small proportion were not virologically suppressed while others, despite being suppressed, were on ≥ 4-drug ART regimens. As such, new therapeutic options are needed to achieve and maintain virologic suppression in such individuals while decreasing their pill burden. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1784-3286; 2295-3337 |
| Relation: |
urn:issn:1784-3286; urn:issn:2295-3337; https://orbi.uliege.be/handle/2268/327339; info:hdl:2268/327339; https://orbi.uliege.be/bitstream/2268/327339/1/A%20characterization%20of%20the%20HIV%20population%20with%20limited%20exhausted%20treatment%20options%20%20a%20multicenter%20Belgian%20study.pdf; info:pmid:38813800 |
| DOI: |
10.1080/17843286.2024.2359184 |
| Availability: |
https://orbi.uliege.be/handle/2268/327339; https://orbi.uliege.be/bitstream/2268/327339/1/A%20characterization%20of%20the%20HIV%20population%20with%20limited%20exhausted%20treatment%20options%20%20a%20multicenter%20Belgian%20study.pdf; https://doi.org/10.1080/17843286.2024.2359184 |
| Rights: |
open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.91B99ACE |
| Database: |
BASE |