| Title: |
Unlocking the Potential of Computed Tomography-Guided Tracers in Pinpointing Lung Lesions during Surgery: A Collaborative Multi-Institutional Journey † |
| Authors: |
Potenza R.; Andolfi M.; Dell'Amore A.; Lugaresi M.; Roca G.; Valentini L.; Catelli C.; Buia F.; Dolci G.; Floridi C.; Moretti R.; Colafigli C.; Refai M.; Rea F.; Puma F.; Daddi N. |
| Contributors: |
Potenza, R.; Andolfi, M.; Dell'Amore, A.; Lugaresi, M.; Roca, G.; Valentini, L.; Catelli, C.; Buia, F.; Dolci, G.; Floridi, C.; Moretti, R.; Colafigli, C.; Refai, M.; Rea, F.; Puma, F.; Daddi, N. |
| Publication Year: |
2024 |
| Collection: |
Università degli Studi di Siena: USiena air |
| Subject Terms: |
bioabsorbable hydrogel plug; hook wire; microcoil |
| Description: |
Background: Multiple techniques exist for the preoperative localization of small, deeply located solid or subsolid pulmonary nodules to guide limited thoracoscopic resection. This study aims to conduct a multi-institutional comparison of three different tomography-guided tracers’ methods. Methods: A retrospective multicenter cross-sectional study was conducted. All patients suitable for CT-guided tracers with microcoil (GROUP1, n = 58), hook wire (GROUP2, n = 86), or bioabsorbable hydrogel plug (GROUP3, n = 33) were scheduled for video-assisted thoracoscopic wedge resection. Outcome variables: successful nodule localization, safety, and the feasibility of the tracers’ placement. A χ2 test or Fisher’s test for expected numbers less than five and a Kruskal–Wallis test were used to analyze the categorical and continuous variables, respectively. For the power calculations, we used G*Power version 3.1.9.6. Results: One hundred seventy-seven patients underwent the localization and resection of 177 nodules detected with three different CT-guided tracers. A significant difference was recorded for cancer history (p = 0.030), respiratory function, Charlson comorbidity index (p = 0.018), lesion type (p < 0.0001), distance from pleura surface (p < 0.0001), and time between preoperative CT-guided tracers and surgical procedures (p < 0.0001). Four post-procedural complications were recorded and in GROUP2, four cases of tracer dislocations occurred. Finally, hook wire group was associated with the shortest surgical time (93 min, p = 0.001). Conclusions: All methods were feasible and efficient, resulting in a 100% success rate for the microcoils and the bioabsorbable hydrogel plugs and a 94.2% success rate for the hook wires. Our results highlight the need to choose a technique that is less stressful for the patient and helps the surgeon by extending the approach to deep nodules and resecting over the course of several days from deployment. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39457991; info:eu-repo/semantics/altIdentifier/wos/WOS:001342658000001; volume:13; issue:20; numberofpages:13; journal:JOURNAL OF CLINICAL MEDICINE; https://hdl.handle.net/11365/1277340; https://pmc.ncbi.nlm.nih.gov/articles/PMC11508513/ |
| DOI: |
10.3390/jcm13206041 |
| Availability: |
https://hdl.handle.net/11365/1277340; https://doi.org/10.3390/jcm13206041; https://www.mdpi.com/2077-0383/13/20/6041; https://pmc.ncbi.nlm.nih.gov/articles/PMC11508513/ |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.920DCFE6 |
| Database: |
BASE |