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Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study

Title:	Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study
Authors:	Antonio Pesenti; John G Laffey; Laurent Brochard; Andres Esteban; Luciano Gattinoni; Frank van Haren; Anders Larsson; Daniel F McAuley; Marco Ranieri; Gordon Rubenfeld; B Taylor Thompson; Hermann Wrigge; Arthur S Slutsky; Giacomo Bellani; Tài Pham; Eddy Fan; Fernando Rios; Thierry Sottiaux; Pieter Depuydt; Fredy S Lora; Luciano Cesar Azevedo; Guillermo Bugedo; Haibo Qiu; Marcos Gonzalez; Juan Silesky; Vladimir Cerny; Jonas Nielsen; Manuel Jibaja; Dimitrios Matamis; Jorge Luis Ranero; Pravin Amin; S M Hashemian; Kevin Clarkson; Kiyoyasu Kurahashi; Asisclo Villagomez; Amine Ali Zeggwagh; Leo M Heunks; Jon Henrik Laake; Jose Emmanuel Palo; Antero do Vale Fernandes; Dorel Sandesc; Yaasen Arabi; Vesna Bumbasierevic; Nicolas Nin; Jose A Lorente; Lise Piquilloud; Fekri Abroug; Lia McNamee; Javier Hurtado; Ed Bajwa; Gabriel Démpaire; Hektor Sula; Lordian Nunci; Alma Cani; Alan Zazu; Christian Dellera; Carolina S Insaurralde; Risso V Alejandro; Julio Daldin; Mauricio Vinzio; Ruben O Fernandez; Luis P Cardonnet; Lisandro R Bettini; Mariano Carboni Bisso; Emilio M Osman; Mariano G Setten; Pablo Lovazzano; Javier Alvarez; Veronica Villar; Norberto C Pozo; Nicolas Grubissich; Gustavo A Plotnikow; Daniela N Vasquez; Santiago Ilutovich; Norberto Tiribelli; Ariel Chena; Carlos A Pellegrini; María G Saenz; Elisa Estenssoro; Matias Brizuela; Hernan Gianinetto; Pablo E Gomez; Valeria I Cerrato; Marco G Bezzi; Silvina A Borello; Flavia A Loiacono; Adriana M Fernandez; Serena Knowles; Claire Reynolds; Deborah M Inskip; Jennene J Miller; Jing Kong; Christina Whitehead; Shailesh Bihari; Aylin Seven; Amanda Krstevski; Helen J Rodgers; Rebecca T Millar; Toni E McKenna; Irene M Bailey; Gabrielle C Hanlon; Anders Aneman; Joan M Lynch; Raman Azad; John Neal; Paul W Woods; Brigit L Roberts; Mark R Kol; Helen S Wong; Katharina C Riss; Thomas Staudinger; Xavier Wittebole; Caroline Berghe; Pierre A Bulpa; Alain M Dive; Rik Verstraete; Herve Lebbinck; Joris Vermassen; Philippe Meersseman; Helga Ceunen; Jonas I Rosa; Daniel O Beraldo; Claudio Piras; Adenilton M Rampinelli; Antonio P Nassar Jr; Sergio Mataloun; Marcelo Moock; Marlus M Thompson; Claudio H Gonçalves; Ana Carolina P Antônio; Aline Ascoli; Rodrigo S Biondi; Danielle C Fontenele; Danielle Nobrega; Vanessa M Sales; Ahmad Yazid Bin Hj Abul Wahab; Maizatul Ismail; Suresh Shindhe; John Laffey; Francois Beloncle; Kyle G Davies; Rob Cirone; Venika Manoharan; Mehvish Ismail; Ewan C Goligher; Mandeep Jassal; Erin Nishikawa; Areej Javeed; Gerard Curley; Nuttapol Rittayamai; Matteo Parotto; Niall D Ferguson; Sangeeta Mehta; Jenny Knoll; Antoine Pronovost; Sergio Canestrini; Alejandro R Bruhn; Patricio H Garcia; Felipe A Aliaga; Pamela A Farías; Jacob S Yumha; Claudia A Ortiz; Javier E Salas; Alejandro A Saez; Luis D Vega; Eduardo F Labarca; Felipe T Martinez; Nicolás G Carreño; Pilar Lora; Haitao Liu; Ling Liu; Rui Tang; Xiaoming Luo; Youzhong An; Huiying Zhao; Yan Gao; Zhe Zhai; Zheng L Ye; Wei Wang; Wenwen Li; Qingdong Li; Ruiqiang Zheng; Wenkui Yu; Juanhong Shen; Xinyu Li; Tao Yu; Weihua Lu; Ya Q Wu; Xiao B Huang; Zhenyang He; Yuanhua Lu; Hui Han; Fan Zhang; Renhua Sun; Hua X Wang; Shu H Qin; Bao H Zhu; Jun Zhao; Jian Liu; Bin Li; Jing L Liu; Fa C Zhou; Qiong J Li; Xing Y Zhang; Zhou Li-Xin; Qiang Xin-Hua; Liangyan Jiang; Yuan N Gao; Xian Y Zhao; Yuan Y Li; Xiao L Li; Chunting Wang; Qingchun Yao; Rongguo Yu; Kai Chen; Huanzhang Shao; Bingyu Qin; Qing Q Huang; Wei H Zhu; Ai Y Hang; Ma X Hua; Yimin Li; Yonghao Xu; Yu D Di; Long L Ling; Tie H Qin; Shou H Wang; Junping Qin; Yi Han; Suming Zhou; Monica P Vargas; Juan I Silesky Jimenez; Manuel A González Rojas; Jaime E SolisQuesada; Christian M Ramirez-Alfaro; Jan Máca; Peter Sklienka; Jakob Gjedsted; Aage Christiansen; Boris G Villamagua; Iguel Llano; Philippe Burtin; Gautier Buzancais; Pascal Beuret; Nicolas Pelletier; Satar Mortaza; Alain Mercat; Jonathan Chelly; Sébastien Jochmans; Nicolas Terzi; Cédric Daubin; Guillaume Carteaux; Nicolas de Prost; Jean-Daniel Chiche; Fabrice Daviaud; Muriel Fartoukh; Guillaume Barberet; Jerome Biehler; Jean Dellamonica; Denis Doyen; Jean-Michel Arnal; Anais Briquet; Sami Hraiech; Laurent Papazian; Arnaud Follin; Damien Roux; Jonathan Messika; Evangelos Kalaitzis; Laurence Dangers; Alain Combes; Siu-Ming Au; Gaetan Béduneau; Dorothée Carpentier; Elie H Zogheib; Herve Dupont; Sylvie Ricome; Francesco L Santoli; Sebastien L Besset; Philippe Michel; Bruno Gelée; Pierre-Eric Danin; Bernard Goubaux; Philippe J Crova; Nga T Phan; Frantz Berkelmans; Julio C Badie; Romain Tapponnier; Josette Gally; Samy Khebbeb; Jean-Etienne Herbrecht; Francis Schneider; PierreLouis M Declercq; Jean-Philippe Rigaud; Jacques Duranteau; Anatole Harrois; Russell Chabanne; Julien Marin; Charlene Bigot; Sandrine Thibault; Mohammed Ghazi; Messabi Boukhazna; Salem Ould Zein; Jack R Richecoeur; Daniele M Combaux; Fabien Grelon; Charlene Le Moal; Elise P Sauvadet; Adrien Robine; Virginie Lemiale; Danielle Reuter; Martin Dres; Alexandre Demoule; Dany Goldgran-Toledano; Loredana Baboi; Claude Guérin; Ralph Lohner; Jens Kraßler; Susanne Schäfer; Kai D Zacharowski; Patrick Meybohm; Andreas W Reske; Philipp Simon; HansBernd F Hopf; Michael Schuetz; Thomas Baltus; Metaxia N Papanikolaou; Theonymfi G Papavasilopoulou; Giannis A Zacharas; Vasilis Ourailogloy; Eleni K Mouloudi; Eleni V Massa; Eva O Nagy; Electra E Stamou; Ellada V Kiourtzieva; Marina A Oikonomou; Luis E Avila; Cesar A Cortez; Johanna E Citalán; Sameer A Jog; Safal D Sable; Bhagyesh Shah; Mohan Gurjar; Arvind K Baronia; Mohammedfaruk Memon; Radhakrishnan Muthuchellappan; Venkatapura J Ramesh; Anitha Shenoy; Ramesh Unnikrishnan; Subhal B Dixit; Rachana V Rhayakar; Nagarajan Ramakrishnan; Vallish K Bhardwaj; Heera L Mahto; Sudha V Sagar; Vijayanand Palaniswamy; Deeban Ganesan; Seyed Mohammadreza Hashemian; Hamidreza Jamaati; Farshad Heidari; Edel A Meaney; Alistair Nichol; Karl M Knapman; Donall O'Croinin; Eimhin S Dunne; Dorothy M Breen; Kevin P Clarkson; Rola F Jaafar; Rory Dwyer; Fahd Amir; Olaitan O Ajetunmobi; Aogan C O'Muircheartaigh; Colin S Black; Nuala Treanor; Daniel V Collins; Wahid Altaf; Gianluca Zani; Maurizio Fusari; Savino Spadaro; CA Volta; Romano Graziani; Barbara Brunettini; Salvatore Palmese; Paolo Formenti; Michele Umbrello; Andrea Lombardo; Elisabetta Pecci; Marco Botteri; Monica Savioli; Alessandro Protti; Alessia Mattei; Lorenzo Schiavoni; Andrea Tinnirello; Manuel Todeschini; Antonino Giarratano; Andrea Cortegiani; Massimo M Antonelli; Luca M Montini; Paolo Casalena; Sergio Scafetti; Giovanna Panarello; Giovanna Occhipinti; Nicolò Patroniti; Matteo Pozzi; Roberto R Biscione; Michela M Poli; Ferdinando Raimondi; Daniela Albiero; Giulia Crapelli; Eduardo Beck; Vincenzo Pota; Vincenzo Schiavone; Alexandre Molin; Fabio Tarantino; Giacomo Monti; Elena Frati; Lucia Mirabella; Gilda Cinnella; Tommaso Fossali; Riccardo Colombo; Pierpaolo Terragni; Ilaria Pattarino; Francesco Mojoli; Antonio Braschi; Erika E Borotto; Andrea N Cracchiolo; Daniela M Palma; Francesco Raponi; Giuseppe Foti; Ettore R Vascotto; Andrea Coppadoro; Luca Brazzi; Leda Floris; Giorgio A Iotti; Aaron Venti; Osamu Yamaguchi; Shunsuke Takagi; Hiroki N Maeyama; Eizo Watanabe; Yoshihiro Yamaji; Kazuyoshi Shimizu; Kyoko Shiozaki; Satoru Futami; Sekine Ryosuke; Koji Saito; Yoshinobu Kameyama; Keiko Ueno; Masayo Izawa; Nao Okuda; Hiroyuki Suzuki; Tomofumi Harasawa; Michitaka Nasu; Tadaaki Takada; Fumihito Ito; Shin Nunomiya; Kansuke Koyama; Toshikazu Abe; Kohkichi Andoh; Kohei Kusumoto; Akira Hirata; Akihiro Takaba; Hiroyasu Kimura; Shuhei Matsumoto; Ushio Higashijima; Hiroyuki Honda; Nobumasa Aoki; Hiroshi Imai; Yasuaki Ogino; Ichiko Mizuguchi; Kazuya Ichikado; Kenichi Nitta; Katsunori Mochizuki; Tomoaki Hashida; Hiroyuki Tanaka; Tomoyuki Nakamura; Daisuke Niimi; Takeshi Ueda; Yozo Kashiwa; Akinori Uchiyama; Olegs Sabelnikovs; Peteris Oss; Youssef Haddad; Kong Y Liew; Silvio A Ñamendys-Silva; Yves D Jarquin-Badiola; Luis A Sanchez-Hurtado; Saira S Gomez-Flores; Maria C Marin; Asisclo J Villagomez; Jordana S Lemus; Jonathan M Fierro; Mavy Ramirez Cervantes; Francisco Javier Flores Mejia; Dulce Dector; Alejandro Rojas; Daniel R Gonzalez; Claudia R Estrella; Jorge R Sanchez-Medina; Alvaro Ramirez-Gutierrez; Fernando G George; Janet S Aguirre; Juan A Buensuseso; Manuel Poblano; Tarek Dendane; Hicham Balkhi; Mina Elkhayari; Nacer Samkaoui; Hanane Ezzouine; Abdellatif Benslama; Mourad Amor; Wajdi Maazouzi; Nedim Cimic; Oliver Beck; Monique M Bruns; Jeroen A Schouten; Myra Rinia; Monique Raaijmakers; Hellen M van Wezel; Serge J Heines; Ulrich Strauch; Marc P Buise; Fabienne D Simonis; Marcus J Schultz; Jennifer C Goodson; Troy S Browne; Leanlove Navarra; Anna Hunt; Robyn A Hutchison; Mathew B Bailey; Lynette Newby; Colin McArthur; Michael Kalkoff; Alex Mcleod; Jonathan Casement; Danielle J Hacking; Finn H Andersen; Merete S Dolva; Jon H Laake; Andreas Barratt-Due; Kim Andre L Noremark; Eldar Søreide; Brit Å Sjøbø; Anne B Guttormsen; Hector H Leon Yoshido; Ronald Zumaran Aguilar; Fredy A Montes Oscanoa; Alain U Alisasis; Joanne B Robles; Rossini Abbie B Pasanting-Lim; Beatriz C Tan; Pawel Andruszkiewicz; Karina Jakubowska; Cristina M Coxo; António M Alvarez; Bruno S Oliveira; Gustavo M Montanha; Nelson C Barros; Carlos S Pereira; António M Messias; Jorge M Monteiro; Ana M Araujo; Nuno T Catorze; Susan M Marum; Maria J Bouw; Rui M Gomes; Vania A Brito; Silvia Castro; Joana M Estilita; Filipa M Barros; Isabel M Serra; Aurelia M Martinho; Dana R Tomescu; Alexandra Marcu; Ovidiu H Bedreag; Marius Papurica; Dan E Corneci; Silvius Ioan Negoita; Evgeny Grigoriev; Alexey I Gritsan; Andrey A Gazenkampf; Ghaleb Almekhlafi; Mohamad M Albarrak; Ghanem M Mustafa; Khalid A Maghrabi; Nawal Salahuddin; Tharwat M Aisa; Ahmed S Al Jabbary; Edgardo Tabhan; Yaseen M Arabi; Olivia A Trinidad; Hasan M Al Dorzi; Edgardo E Tabhan; Vesna Bumbasirevic; Bojan Jovanovic; Stefan Bolon; Oliver Smith; Jordi Mancebo; Hernan Aguirre-Bermeo; Juan C Lopez-Delgado; Francisco Esteve; Gemma Rialp; Catalina Forteza; Candelaria De Haro; Antonio Artigas; Guillermo M Albaiceta; Sara De Cima-Iglesias; Leticia Seoane-Quiroga; Alexandra Ceniceros-Barros; Antonio L RuizAguilar; Luis M Claraco-Vega; Juan Alfonso Soler; Maria Del Carmen Lorente; Cecilia Hermosa; Federico Gordo; Miryam PrietoGonzález; Juan B López-Messa; Manuel P Perez; Cesar P Perez; Raquel Montoiro Allue; Ferran RocheCampo; Marcos Ibañez-Santacruz; Susana TempranoSusana; Maria C Pintado; Raul De Pablo; Pilar Ricart Aroa Gómez; Silvia Rodriguez Ruiz; Silvia Iglesias Moles; Ma Teresa Jurado; Alfons Arizmendi; Enrique A Piacentini; Nieves Franco; Teresa Honrubia; Meisy Perez Cheng; Elena Perez Losada; Javier Blanco; Luis J Yuste; Cecilia Carbayo-Gorriz; Francisca G Cazorla-Barranquero; Javier G Alonso; Rosa S Alda; Ángela Algaba; Gonzalo Navarro; Enrique Cereijo; Esther Diaz-Rodriguez; Diego Pastor Marcos; Laura Alvarez Montero; Luis Herrera Para; Roberto Jimenez Sanchez; Miguel Angel Blasco Navalpotro; Ricardo Diaz Abad; Raquel Montiel González; Dácil Parrilla Toribio; Alejandro G Castro; Maria Jose D Artiga; Oscar Penuelas; Tomas P Roser; Moreno F Olga; Elena Gallego Curto; Rocío Manzano Sánchez; Vallverdu P Imma; Garcia M Elisabet; Laura Claverias; Monica Magret; Ana M Pellicer; Lucia L Rodriguez; Jesús Sánchez-Ballesteros; Ángela González-Salamanca; Antonio G Jimenez; Francisco P Huerta; Juan Carlos J Sotillo Diaz; Esther Bermejo Lopez; David D Llinares Moya; Alec A Tallet Alfonso; Palazon Sanchez Eugenio Luis; Palazon Sanchez Cesar; Sánchez I Rafael; Corcoles G Virgilio; Noelia N Recio; Christian C Rylander; Bernhard Holzgraefe; Lars M Broman; Joanna Wessbergh; Linnea Persson; Fredrik Schiöler; Hans Kedelv; Anna Oscarsson Tibblin; Henrik Appelberg; Lars Hedlund; Johan Helleberg; Karin E Eriksson; Rita Glietsch; Niklas Larsson; Ingela Nygren; Silvia L Nunes; Anna-Karin Morin; Thomas Kander; Anne Adolfsson; Hervé O Zender; Corinne Leemann-Refondini; Souheil Elatrous; Slaheddine Bouchoucha; Imed Chouchene; Islem Ouanes; Asma Ben Souissi; Salma Kamoun; Oktay Demirkiran; Mustafa Aker; Emre Erbabacan; Ilkay Ceylan; Nermin Kelebek Girgin; Menekse Ozcelik; Necmettin Ünal; Basak Ceyda Meco; Onat O Akyol; Suleyman S Derman; Barry Kennedy; Ken Parhar; Latha Srinivasa; Danny McAuley; Phil Hopkins; Clare Mellis; Vivek Kakar; Dan Hadfield; Andre Vercueil; Kaushik Bhowmick; Sally K Humphreys; Andrew Ferguson; Raymond Mckee; Ashok S Raj; Danielle A Fawkes; Philip Watt; Linda Twohey; Rajeev R Jha; Matthew Thomas; Alex Morton; Varsha Kadaba; Mark J Smith; Anil P Hormis; Santhana G Kannan; Miriam Namih; Henrik Reschreiter; Julie Camsooksai; Alek Kumar; Szabolcs Rugonfalvi; Christopher Nutt; Orla Oneill; Colette Seasman; Ged Dempsey; Christopher J Scott; Helen E Ellis; Stuart Mckechnie; Paula J Hutton; Nora N Di Tomasso; Michela N Vitale; Ruth O Griffin; Michael N Dean; Julius H Cranshaw; Emma L Willett; Nicholas Ioannou; Sarah Gillis; Peter Csabi; Rosaleen Macfadyen; Heidi Dawson; Pieter D Preez; Alexandra J Williams; Owen Boyd; Laura Ortiz-Ruiz de Gordoa; Jon Bramall; Sophie Symmonds; Simon K Chau; Tim Wenham; Tamas Szakmany; Piroska Toth-Tarsoly; Katie H McCalman; Peter Alexander; Lorraine Stephenson; Thomas Collyer; Rhiannon Chapman; Raphael Cooper; Russell M Allan; Malcolm Sim; David W Wrathall; Donald A Irvine; Kim S Zantua; John C Adams; Andrew J Burtenshaw; Gareth P Sellors; Ingeborg D Welters; Karen E Williams; Robert J Hessell; Matthew G Oldroyd; Ceri E Battle; Suresh Pillai; Istvan Kajtor; Mageswaran Sivashanmugavel; Sinead C Okane; Adrian Donnelly; Aniko D Frigyik; Jon P Careless; Martin M May; Richard Stewart; T John Trinder; Samantha J Hagan; Jade M Cole; Caroline C MacFie; Anna T Dowling; Nicolás Nin; Edgardo Nuñez; Gustavo Pittini; Ruben Rodriguez; María C Imperio; Cristina Santos; Ana G França; Alejandro Ebeid; Alberto Deicas; Carolina Serra; Aditya Uppalapati; Ghassan Kamel; Valerie M Banner-Goodspeed; Jeremy R Beitler; Satyanarayana Reddy Mukkera; Shreedhar Kulkarni; John O Shinn Iii; Dina Gomaa; Christopher Tainter; Jarone Lee; Tomaz MesarJarone Lee; Dale J Yeatts; Jessica Warren; Michael J Lanspa; Russel R Miller; Colin K Grissom; Samuel M Brown; Philippe R Bauer; Ryan J Gosselin; Barrett T Kitch; Jason E Cohen; Scott H Beegle; Shazia Choudry; Renaud M Gueret; Aiman Tulaimat; William Stigler; Hitesh Batra; Nidhi G Huff; Keith D Lamb; Trevor W Oetting; Nicholas M Mohr; Claine Judy; Shigeki Saito; Fayez M Kheir; Fayez Kheir; Adam B Schlichting; Angela Delsing; Daniel R Crouch; Mary Elmasri; Dina Ismail; Kyle R Dreyer; Thomas C Blakeman; Rebecca M Baro; Carolina Quintana Grijalba; Peter C Hou; Raghu Seethala; Imo Aisiku; Galen Henderson; Gyorgy Frendl; Sen-Kuang Hou; Robert L Owens; Ashley Schomer
Contributors:	Pesenti, Antonio; G Laffey, John; Brochard, Laurent; Esteban, Andre; Gattinoni, Luciano; van Haren, Frank; Larsson, Ander; F McAuley, Daniel; Ranieri, Marco; Rubenfeld, Gordon; Taylor Thompson, B; Wrigge, Hermann; S Slutsky, Arthur; Bellani, Giacomo; Pham, Tài; Fan, Eddy; Rios, Fernando; Sottiaux, Thierry; Depuydt, Pieter; S Lora, Fredy; Cesar Azevedo, Luciano; Bugedo, Guillermo; Qiu, Haibo; Gonzalez, Marco; Silesky, Juan; Cerny, Vladimir; Nielsen, Jona; Jibaja, Manuel; Matamis, Dimitrio; Luis Ranero, Jorge; Amin, Pravin; M Hashemian, S; Clarkson, Kevin; Kurahashi, Kiyoyasu; Villagomez, Asisclo; Ali Zeggwagh, Amine; M Heunks, Leo; Henrik Laake, Jon; Emmanuel Palo, Jose; do Vale Fernandes, Antero; Sandesc, Dorel; Arabi, Yaasen; Bumbasierevic, Vesna; Nin, Nicola; A Lorente, Jose; Piquilloud, Lise; Abroug, Fekri; Mcnamee, Lia; Hurtado, Javier; Bajwa, Ed; Démpaire, Gabriel; Sula, Hektor; Nunci, Lordian; Cani, Alma; Zazu, Alan; Dellera, Christian; S Insaurralde, Carolina; V Alejandro, Risso; Daldin, Julio; Vinzio, Mauricio; O Fernandez, Ruben; P Cardonnet, Lui; R Bettini, Lisandro; Carboni Bisso, Mariano; M Osman, Emilio; G Setten, Mariano; Lovazzano, Pablo; Alvarez, Javier; Villar, Veronica; C Pozo, Norberto; Grubissich, Nicola; A Plotnikow, Gustavo; N Vasquez, Daniela; Ilutovich, Santiago; Tiribelli, Norberto; Chena, Ariel; A Pellegrini, Carlo; G Saenz, María; Estenssoro, Elisa; Brizuela, Matia; Gianinetto, Hernan; E Gomez, Pablo; I Cerrato, Valeria; G Bezzi, Marco; A Borello, Silvina; A Loiacono, Flavia; M Fernandez, Adriana; Knowles, Serena; Reynolds, Claire; M Inskip, Deborah; J Miller, Jennene; Kong, Jing
Publication Year:	2021
Collection:	Università degli Studi di Ferrara: CINECA IRIS
Description:	Background: Current incidence and outcome of patients with acute hypoxaemic respiratory failure requiring mechanical ventilation in the intensive care unit (ICU) are unknown, especially for patients not meeting criteria for acute respiratory distress syndrome (ARDS). Methods: An international, multicentre, prospective cohort study of patients presenting with hypoxaemia early in the course of mechanical ventilation, conducted during four consecutive weeks in the winter of 2014 in 459 ICUs from 50 countries (LUNG SAFE). Patients were enrolled with arterial oxygen tension/inspiratory oxygen fraction ratio ≤300 mmHg, new pulmonary infiltrates and need for mechanical ventilation with a positive end-expiratory pressure of ≥5 cmH2O. ICU prevalence, causes of hypoxaemia, hospital survival and factors associated with hospital mortality were measured. Patients with unilateral versus bilateral opacities were compared. Findings: 12 906 critically ill patients received mechanical ventilation and 34.9% with hypoxaemia and new infiltrates were enrolled, separated into ARDS (69.0%), unilateral infiltrate (22.7%) and congestive heart failure (CHF; 8.2%). The global hospital mortality was 38.6%. CHF patients had a mortality comparable to ARDS (44.1% versus 40.4%). Patients with unilateral-infiltrate had lower unadjusted mortality, but similar adjusted mortality compared to those with ARDS. The number of quadrants on chest imaging was associated with an increased risk of death. There was no difference in mortality comparing patients with unilateral-infiltrate and ARDS with only two quadrants involved. Interpretation: More than one-third of patients receiving mechanical ventilation have hypoxaemia and new infiltrates with a hospital mortality of 38.6%. Survival is dependent on the degree of pulmonary involvement whether or not ARDS criteria are reached
Document Type:	article in journal/newspaper
File Description:	STAMPA
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/33334944; info:eu-repo/semantics/altIdentifier/wos/WOS:000670910500005; volume:57; issue:6; firstpage:2003317-1; lastpage:2003317-17; numberofpages:17; journal:EUROPEAN RESPIRATORY JOURNAL; https://hdl.handle.net/11392/2470359; https://erj.ersjournals.com/content/57/6/2003317
DOI:	10.1183/13993003.03317-2020
Availability:	https://hdl.handle.net/11392/2470359; https://doi.org/10.1183/13993003.03317-2020; https://erj.ersjournals.com/content/57/6/2003317
Rights:	info:eu-repo/semantics/openAccess ; license:PUBBLICO - Pubblico con Copyright ; license uri:iris.PUB02
Accession Number:	edsbas.92517991
Database:	BASE