| Title: |
Carpenter Syndrome – Case Report and Treatment |
| Authors: |
Mirchevski, Vladimir; Zogovska, Elizabeta; Chaparoski, Aleksandar; Filipce, Venko; Agai, Ljuljzim; Shuntov, Blagoj; Mirchevski, Mirko Michel; Srceva, Marija Jovanovska |
| Source: |
Macedonian Medical Review ; volume 70, issue 2, page 99-103 ; ISSN 0025-1097 |
| Publisher Information: |
Walter de Gruyter GmbH |
| Publication Year: |
2016 |
| Description: |
Introduction. Carpenter syndrome is a polymorphic disorder transmitted by autosomal recessive inheritance, caused by mutations in the RAB23 gene [1]. These genetic disorders are reflected on the biogenesis of intracranial structures. This syndrome was described for the first time in 1900 by the British doctor George Carpenter. It may include congenital heart diseases, mental retardation, hypogonadism, obesity, umbilical hernia, developmental disorder, bone anomalies and frequent respiratory infections. Carpenter syndrome has two main features: craniosynostosis and more than five fingers or toes [2-4]. Aim. To present our experience in treatment of an infant with Carpenter syndrome including trigonocephaly and polydactyly. Case report. In May 2003, an eleven-month-old male infant with Carpenter syndrome was hospitalized in the Pediatric Department of the University Clinic of Neurosurgery in Skopje, Republic of Macedonia. The infant was referred to our Department from the University Pediatric Clinic because of trigonocephaly and polydactyly with two thumbs on his right hand. The infant had already been twice hospitalized at the University Pediatric Clinic for two recurrent lung infections suggestive of Carpenter syndrome. The diagnosis of trigonocephaly and polydactyly with two thumbs on the right hand was made by physical examination, X-ray of the right infant’s hand and computed tomography of the head. According to Oi and Matsumoto classification from 1986 [5], the infant had a severe form of trigonocephaly. Surgical procedure. Under general endotracheal anesthesia, the infant was placed supine on the operating table, a bifrontal skin incision was made and the scalp flap was created. The bifrontal craniotomy was realized into one bony piece succeeded by a modified Di Rocco’s "shell" procedure including frontal translation and transposition rotating the flap for 180 degrees without /touching the orbital rims. Results. The postoperative period was uneventful except for the expected forehead swelling. The ... |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.1515/mmr-2016-0019 |
| Availability: |
https://doi.org/10.1515/mmr-2016-0019; http://content.sciendo.com/view/journals/mmr/70/2/article-p99.xml; http://www.degruyter.com/view/j/mmr.2016.70.issue-2/mmr-2016-0019/mmr-2016-0019.pdf |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0 |
| Accession Number: |
edsbas.92541FE4 |
| Database: |
BASE |