| Title: |
Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study |
| Authors: |
K Aizawa; PE Gates; DM Mawson; F Casanova; KM Gooding; SV Hope; I Goncalves; J Nilsson; F Khan; HM Colhoun; A Natali; C Palombo; AC Shore |
| Publication Year: |
2023 |
| Collection: |
Erasmus University Rotterdam (EUR): Figshare |
| Subject Terms: |
Aging; Aorta; Blood pressure; Ultrasound |
| Description: |
Greater central artery stiffness is observed in people with Type 2 diabetes (T2DM). Elevated blood pressure (BP) and altered arterial wall structure/composition in T2DM are generally considered as main drivers for this alteration. However, because conventional arterial stiffness measures are BP-dependent and as such an influence of BP remains in a measure, it is unclear if greater central artery stiffness is a function of greater BP, or due to changes in the structure and composition of the arterial wall. We aimed to measure BP-independent arterial stiffness (β0) cross-sectionally and longitudinally in T2DM. We studied 753 adults with T2DM (DM+) and 436 adults without (DM-) at baseline (Phase 1), and 310 DM+ and 210 DM- adults at three-year follow-up (Phase 2). We measured carotid-femoral pulse wave velocity and used it to calculate β0. In Phase 1, β0 was significantly greater in DM+ than DM- after adjusting for age and sex [27.5 (26.6-28.3) vs 23.6 (22.4-24.8) au, p |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
10871/134692 |
| Availability: |
https://figshare.com/articles/journal_contribution/Type_2_diabetes_exacerbates_changes_in_blood_pressure-independent_arterial_stiffness_cross-sectional_and_longitudinal_evidence_from_the_SUMMIT_study/29806424 |
| Rights: |
All rights reserved |
| Accession Number: |
edsbas.92D34D93 |
| Database: |
BASE |