| Title: |
Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort |
| Authors: |
Foster, G; Coppola, C; Derbala, M; Ferenci, P; Orlandini, A; Reddy, K; Tallarico, L; Shiffman, M; Ahlers, S; Bakalos, G; Hassanein, T; Basho, J; Shabanaj, G; Harxhi, A; Debzi, N; Afredj, N; Guessab, N; Mahindad, N; Mahiou, H; Aissaoui, M; Al Qameesh, J; Al Ghandoor, Z; Assene, C; Bastens, B; Brixko, C; Cool, M; De Galocsy, C; Delwaide, J; George, C; Laukens, P; Lefebvre, V; Mulkay, J; Nevens, F; Servais, B; Van Vlierberghe, H; Horsmans, Y; Henrion, J; Sprengers, D; Michielsen, P; Bourgeois, S; Lasser, L; Langlet, P; Robaeys, G; Martinet, J; Warzee, P; Hoste, P; Reynaert, H; Juriens, I; Decaestecker, J; Van Der Meersch, F; Janssens, F; Ahmetagic, S; Verhaz, A; Bevanda, M; Calkic, L; Ibrahimpasic, N; Mesihovic, R; Mello, C; Ruiz, F; Junior, E; Ferraz, M; Silva, G; Mendes, C; Lyra, A; Silva, M; Gomide, G; Fernandes, J; Pereira, P; Correa, M; Teixeira, R; Yousry, A; Hanno, A; Gabr, M; Omar, A; Esmat, G; Karatapanis, S; Nikolopoulou, V; Giannoulis, G; Manolakopoulos, S; Elefsiniotis, I; Drakoulis, C; Dimitroulopoulos, D; Kanatakis, S; Ketikoglou, I; Mimidis, K; Evgenidis, N; Akriviades, E; Vafiadi Zoubouli, I; Tsianos, E; Mela, M; Orfanou, E; Mousoulis, G; Karagiannis, I; Manesis, E; Varga, M; Nemesánszky, E; Fried, K; Schuller, J; Szalay, F; Lengyel, G; Tornai, I; Banyai, T; Lesch, M; Nagy, I; Gervain, J; Tusnadi, A; Schneider, F; Szentgyörgyi, L; Hunyady, B; Vincze, A; Tolvaj, G; Varkonyi, I; Makkai, E; Enyedi, J; Racz, I; Hausinger, P; Váczi, Z; Patai, Á; Ozsvár, Z; Lakner, L; Ribiczey, P; Bhalla, A; Somani, S; Luaia, R; Rao, P; Philip, M; Lawate, P; Nagral, A; Sood, A; Parikh, S; Merat, S; Nassiri Toosi, M; Alavian, S; Zali, M; Daryani, N; Drenaggi, D; Attili, A; Bandiera, F; Bassi, P; Bellati, G; Bellantani, S; Brunetto, M; Bruno, S; Castelli, F; Castellacci, R; Cattelan, A; Colombo, M; Craxi, A; D'angelo, S; Colombo, S; Demelia, L; Di Perri, G; Di Giacomo, A; Ferrari, C; Francisci, D; Casinelli, K; Ganga, R; Costa, C; Mangia, A; Russo, F; Matarazzo, F; Mazzella, G; Mazzeo, M; Memoli, M; Montalbano, M; Montalto, G; Pieri, A; Passariello, N; Picciotto, A; Pietrangelo, A; Pirisi, M; Quirino, T; Raimondo, G; Rapaccini, G; Rizzardini, G; Rizzetto, M; Russello, M; Sabusco, G; Santantonio, T; Amedea, A; Verucchi, G; Vinelli, F; Zignego, A; Zuin, M; Ascione, A; Vinci, M; Pigozzi, M; Tundo, P; Saracco, G; Amoroso, P; Andreoni, M; Colletta, C; Erne, E; Megna, A; Biglino, A; Chiriaco, P; Foti, G; Spinzi, G; D'amico, E; Paik, S; Ahn, S; Lee, Y; Kim, Y; Yang, J; Han, S; Varghese, R; Al Gharabally, A; Askar, H; Sharara, A; Yaghi, C; Abou Rached, A; Houmani, Z; Zaarour, F; Dohaibi, A; Ivanovski, L; Joksimovic, N; Abbas, Z; Memon, S; Mohsin, A; Masood, S; Hashmi, Z; Halota, W; Deron, Z; Mazur, W; Flisiak, R; Lipczynski, A; Musialik, J; Piekarska, A; Augustyniak, K; Baka Cwierz, B; Simon, K; Gietka, A; Berak, H; Sieklucki, J; Radowska, D; Szlauer, B; Piekos, T; Olszok, I; Jablkowski, M; Orszulak, G; Warakomska, I; Aleixo, M; Valente, C; Macedo, G; Sarmento Castro, R; Roxo, F; Faria, T; Mansinho, K; Velez, J; Ramos, J; Guerreiro, H; Alberto, S; Monteverde, C; Serejo, F; Peixe, P; Malhado, J; Curescu, M; Streinu Cercel, A; Caruntu, F; Livia, H; Preotescu, L; Arama, V; Ancuta, I; Gheorghe, L; Stanciu, C; Trifan, A; Acalovschi, M; Andreica, V; Pascu, O; Lencu, M; Sporea, I; Olteanu, D; Ionita Radu, F; Fierbinteanu Braticevici, C; Motoc, A; Silaghi, R; Musat, M; Coman, F; Stan, M; Cijevschi, C; Miftode, E; Delic, D; Jesic, R; Nozic, D; Svorcan, P; Fabri, M; Konstantinovic, L; Pelemis, M; Jankovic, G; Todorovic, Z; Nagorni, A; Kupcova, V; Skladany, L; Szantova, M; Krkoska, D; Jarcuska, P; Schreter, I; Oltman, M; Bocakova, J; Bunganic, I; Holoman, J; Giguere, A; Abdou, A. M. S. ai; SOARDO, GIORGIO |
| Contributors: |
Foster, G; Coppola, C; Derbala, M; Ferenci, P; Orlandini, A; Reddy, K; Tallarico, L; Shiffman, M; Ahlers, S; Bakalos, G; Hassanein, T; Basho, J; Shabanaj, G; Harxhi, A; Debzi, N; Afredj, N; Guessab, N; Mahindad, N; Mahiou, H; Aissaoui, M; Al Qameesh, J; Al Ghandoor, Z; Assene, C; Bastens, B; Brixko, C; Cool, M; De Galocsy, C; Delwaide, J; George, C; Laukens, P; Lefebvre, V; Mulkay, J; Nevens, F; Servais, B; Van Vlierberghe, H; Horsmans, Y; Henrion, J; Sprengers, D; Michielsen, P; Bourgeois, S; Lasser, L; Langlet, P; Robaeys, G; Martinet, J; Warzee, P; Hoste, P; Reynaert, H; Juriens, I; Decaestecker, J; Van Der Meersch, F; Janssens, F; Ahmetagic, S; Verhaz, A; Bevanda, M; Calkic, L; Ibrahimpasic, N; Mesihovic, R; Mello, C; Ruiz, F; Junior, E; Ferraz, M; Silva, G; Mendes, C; Lyra, A; Silva, M; Gomide, G; Fernandes, J; Pereira, P; Correa, M; Teixeira, R; Yousry, A; Hanno, A; Gabr, M; Omar, A; Esmat, G; Karatapanis, S; Nikolopoulou, V; Giannoulis, G; Manolakopoulos, S; Elefsiniotis, I; Drakoulis, C; Dimitroulopoulos, D; Kanatakis, S; Ketikoglou, I; Mimidis, K; Evgenidis, N; Akriviades, E; Vafiadi Zoubouli, I; Tsianos, E; Mela, M; Orfanou, E; Mousoulis, G; Karagiannis, I; Manesis, E; Varga, M; Nemesánszky, E; Fried, K; Schuller, J; Szalay, F; Lengyel, G |
| Publication Year: |
2016 |
| Collection: |
Università degli Studi di Udine: CINECA IRIS |
| Description: |
BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000467706800001; volume:11; issue:3; firstpage:1; lastpage:20; numberofpages:20; journal:PLOS ONE; http://hdl.handle.net/11390/1095310; e0151703. doi:10.1371/journal. |
| Availability: |
http://hdl.handle.net/11390/1095310 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.92EBCC73 |
| Database: |
BASE |