| Title: |
A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice |
| Authors: |
Hackstein, C-P; Costigan, D; Drexhage, L; Pearson, C; Bullers, S; Ilott, N; Akther, HD; Gu, Y; FitzPatrick, MEB; Harrison, OJ; Garner, LC; Mann, EH; Pandey, S; Friedrich, M; Provine, NM; Uhlig, HH; Marchi, E; Powrie, F; Klenerman, P; Thornton, EE |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2023 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling, antigen-specific T cells are poised to respond to local insults, making their phenotype important in the relationship between host and microbes. Here we show that MHC-II restricted, commensal-reactive T cells in the colon of both humans and mice acquire transcriptional and functional characteristics associated with innate-like T cells. This cell population is abundant and conserved in the human and murine colon and endowed with polyfunctional effector properties spanning classic Th1- and Th17-cytokines, cytotoxic molecules, and regulators of epithelial homeostasis. T cells with this phenotype are increased in ulcerative colitis patients, and their presence aggravates pathology in dextran sodium sulphate-treated mice, pointing towards a pathogenic role in colitis. Our findings add to the expanding spectrum of innate-like immune cells positioned at the frontline of intestinal immune surveillance, capable of acting as sentinels of microbes and the local cytokine milieu. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41467-022-35126-3 |
| Availability: |
https://doi.org/10.1038/s41467-022-35126-3; https://ora.ox.ac.uk/objects/uuid:3406fe00-7e0e-4289-b403-ba2c714efd7e |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.92EFE66B |
| Database: |
BASE |