| Title: |
Impact of central nervous system involvement in adult patients with Philadelphia-negative acute lymphoblastic leukemia : a GRAALL-2005 study |
| Authors: |
Orvain, Corentin; Chantepie, Sylvain; Thomas, Xavier; Escofrre-Barbe, Martine; Huguet, Francoise; Desbrosses, Yohan; Guillerm, Gaelle; Uzunov, Madalina; Leguay, Thibaut; Barbieux, Sarah; Vey, Norbert; Chevallier, Patrice; Malfuson, Jean-Valere; Lepretre, Stephane; Baumann, Michael; Aykut, Murat; Chaib, Abdelaziz; Joris, Magalie; Zerazhi, Hacene; Stussi, Georg; Chapiro, Jacques; Berthon, Celine; Bonmati, Caroline; Jourdan, Eric; Carp, Diana; Marcais, Amb Roise; Gallego-Hernanz, Maria-Pilar; Vaida, Iona; Bilger, Karin; Villate, Alban; Pasquier, Florence; Chalandon, Yves; Maury, Sebastien; Lheritier, Veronique; Ifrah, Norbert; Dombret, Herve; Boissel, Nicolas; Hunault-Berger, Mathilde; Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL); France-Belgium Group or Lymphoblastic Acute Leukemia in Adults (LALA); French Western- Eastern Group for Lymphoblastic Acute Leukemia (GOELAL); Swiss Group for Clinical Cancer Research (SAKK) |
| Source: |
ISSN: 0390-6078 ; Haematologica, vol. 108, no. 12 (2023) p. 3287-3297. |
| Publication Year: |
2023 |
| Collection: |
Université de Genève: Archive ouverte UNIGE |
| Subject Terms: |
info:eu-repo/classification/ddc/616; Young Adult; Humans; Prospective Studies; Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications; Cyclophosphamide; Hematopoietic Stem Cell Transplantation; Central Nervous System; Treatment Outcome |
| Description: |
Whereas the prognosis of adult patients with Philadelphia-negative acute lymphoblastic leukemia (ALL) has greatly improved since the advent of pediatric-inspired regimens, the impact of initial central nervous system (CNS) involvement has not been formerly re-evaluated. We report here the outcome of patients with initial CNS involvement included in the pediatric-inspired prospective randomized GRAALL-2005 study. Between 2006 and 2014, 784 adult patients (aged 18-59 years) with newly diagnosed Philadelphia-negative ALL were included, of whom 55 (7%) had CNS involvement. In CNSpositive patients, overall survival was shorter (median 1.9 years vs. not reached, HR=1.8 [1.3-2.6], P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36891751; unige:179652 |
| Availability: |
https://archive-ouverte.unige.ch/unige:179652 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.92FC5FD8 |
| Database: |
BASE |