| Title: |
E-Health Intervention for Fear of Cancer Recurrence:A Randomized Clinical Trial |
| Authors: |
Lyhne, Johanne Dam; Smith, Allan Ben; Timm, Signe; Klein, Britt; Thewes, Belinda; Girgis, Afaf; Bamgboje-Ayodele, Adeola; Beatty, Lisa; Fardell, Joanna; Fink, Per; Butow, Phyllis; Frostholm, Lisbeth; Jensen, Lars Henrik |
| Source: |
Lyhne, J D, Smith, A B, Timm, S, Klein, B, Thewes, B, Girgis, A, Bamgboje-Ayodele, A, Beatty, L, Fardell, J, Fink, P, Butow, P, Frostholm, L & Jensen, L H 2025, 'E-Health Intervention for Fear of Cancer Recurrence : A Randomized Clinical Trial', JAMA network open, vol. 8, no. 11, e2542112. https://doi.org/10.1001/jamanetworkopen.2025.42112 |
| Publication Year: |
2025 |
| Collection: |
Aarhus University: Research |
| Subject Terms: |
Humans; Female; Male; Middle Aged; Fear/psychology; Neoplasm Recurrence; Local/psychology; Cancer Survivors/psychology; Aged; Colorectal Neoplasms/psychology; Denmark; Telemedicine; Adult |
| Description: |
Importance: Despite the availability of effective interventions, fear of cancer recurrence (FCR) remains a prevalent concern among cancer survivors, underscoring the need for approaches that balance accessibility (eg, an online program with asynchronous therapist guidance) with engagement and effectiveness. Objective: To evaluate the efficacy of a 10-week therapist-guided (TG) e-health intervention, TG-iConquerFear, to reduce FCR in colorectal cancer (CRC) survivors. Design, Setting, and Participants: This single-site, Danish population-based randomized clinical trial enrolled cancer-free adult CRC survivors aged 18 years or older from May 8, 2023, to April 8, 2024, with clinical FCR (FCR Inventory-Short Form [FCRI-SF] score ≥22). Eligible participants had completed curative-intent CRC treatment between March 1, 2014, and December 31, 2018. Follow-up was 6 months. Interventions: Participants were randomized 1:1 (stratified by age and sex) to receive TG-iConquerFear or augmented control. TG-iConquerFear comprised 6 modules with written therapist guidance delivered remotely, individually, and asynchronously as needed over 10 weeks. Augmented control was a diagnostic interview and referral to a webpage with self-help mindfulness exercises. Main Outcomes and Measures: The primary outcome was change in FCRI total score at 3 months postintervention, analyzed according to intention-to-treat. Results: Of 9946 eligible CRC survivors, 103 with clinically significant FCR were randomized. Prior to the intervention, 2 were excluded due to cancer and 6 dropped out. Of the remaining 95 participants (median age, 63 [IQR 57-72] years; 60 [63%] female; median time since diagnosis, 7 [IQR 6-9] years), 42 were analyzed in the TG-iConquerFear group and 53 in the augmented control group. Intervention participants completed a mean (SD) of 4.5 (1.9) of 6 modules. Total FCRI score decreased significantly from baseline to 3 months in the TG-iConquerFear group (mean change, -21.7 [95% CI, -30.1 to -13.3] points) but not in the control ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2574-3805 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41217757; info:eu-repo/semantics/altIdentifier/pissn/2574-3805; info:eu-repo/semantics/altIdentifier/eissn/2574-3805 |
| DOI: |
10.1001/jamanetworkopen.2025.42112 |
| Availability: |
https://pure.au.dk/portal/en/publications/33e977de-2f9f-4233-ac04-fcd5366d18f3; https://doi.org/10.1001/jamanetworkopen.2025.42112; https://www.scopus.com/pages/publications/105021372160 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.93357859 |
| Database: |
BASE |