| Title: |
Maintenance Chemotherapy in Patients With High-Risk Rhabdomyosarcoma:Long-Term Survival Analysis of the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 Trial |
| Authors: |
Bisogno,Gianni; Chisholm,Julia; Hladun,Raquel; De Salvo,Gian Luca; Guerin,Florent; Casanova,Michela; Mandeville,Henry; Alaggio,Rita; Coppadoro,Beatrice; Orbach,Daniel; Ferrari,Andrea; van Rijn,Rick; Defachelles,Anne-Sophie; Ben-Arush,Myriam; Glosli,Heidi; Cesen,Maja; Merks, Johannes H M; Minard-Colin,Véronique; Onderzoek Beeld |
| Publication Year: |
2025 |
| Subject Terms: |
Taverne; Oncology; Cancer Research; Journal Article |
| Description: |
The European Paediatric Soft Tissue Sarcoma Study Group (EpSSG) RMS 2005 trial evaluated maintenance chemotherapy in high-risk rhabdomyosarcoma (RMS). Patients were randomly assigned to either discontinue treatment (standard arm) or receive six 28-day cycles of vinorelbine (25 mg/m2) once per day on days 1, 8, and 15, plus once daily low-dose cyclophosphamide (25 mg/m2; experimental arm). Initial results showed improved overall survival (OS), but disease-free survival (DFS) improvement was not statistically significant. This report presents mature survival outcomes after extended follow-up. Between April 2006 and December 2016, 186 patients were enrolled in the standard arm and 185 in the experimental arm. After a median follow-up of 122.1 months from diagnosis and 114 months from random assignment, recurrence, progression, or death occurred in 103 patients (61 standard arm, 42 experimental arm). The 10-year DFS was 66.5% (95% CI, 59 to 74) in the standard arm versus 77.1% (95% CI, 70.3 to 82.5) in the experimental arm (P =.025). Corresponding 10-year OS rates were 70.8% (95% CI, 63.3 to 77.0) and 82.9% (95% CI, 76.6 to 87.7; P =.0099). Long-term results of the RMS2005 trial confirm the survival benefit of maintenance chemotherapy with vinorelbine and low-dose cyclophosphamide for patients with high-risk RMS. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0732-183X |
| Relation: |
https://dspace.library.uu.nl/handle/1874/465718 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/465718 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.9358C606 |
| Database: |
BASE |