| Title: |
Binuclear Lanthanide Complexes as Magnetic Resonance and Optical Imaging Probes for Redox Sensing |
| Authors: |
Simms, Charlie H; Kovacs, Daniel; Hacker, Lina; Sarson, Euan T; Sokolova, Daria; Christensen, Kirsten E; Khrapichev, Alexandr; Martin, Louise AW; Vincent, Kylie; Conway, Stuart J; Hammond, Ester M; Langton, Matthew J; Faulkner, Stephen |
| Source: |
Chemistry - A European Journal, vol 31, iss 30 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2025 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3402 Inorganic Chemistry (for-2020); 34 Chemical Sciences (for-2020); Biomedical Imaging (rcdc); 4.1 Discovery and preclinical testing of markers and technologies (hrcs-rac); luminescence; magnetic resonance; optical; redox; sensing; 03 Chemical Sciences (for); General Chemistry (science-metrix) |
| Description: |
We report a family of lanthanide(III) complexes that act as redox probes via both magnetic resonance (MR) and luminescence outputs. The ligands are functionalized with nitro, azobenzene and azide groups which are reduced to a common aniline product, and each responds to both chemical and biocatalytic reductive conditions at different cathodic onset potentials. By judicious choice of complexed Ln(III), the probes can be optimized either for use in MR imaging (Ln=Gd), or as highly efficient turn-on luminescence probes (Ln=Tb). The Tb(III) analogues are essentially nonemissive, until reductive generation of the aniline affords a complex which when excited by visible light (488nm) emits green light with a quantum yield of 45% and millisecond long luminescent lifetimes (ms). The tunable redox response and imaging modalities of these versatile complexes have the potential to open up new approaches to redox sensing, such as the imaging of hypoxic environments in biology. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
qt8nm7c0zh; https://escholarship.org/uc/item/8nm7c0zh |
| DOI: |
10.1002/chem.202404748 |
| Availability: |
https://escholarship.org/uc/item/8nm7c0zh; https://doi.org/10.1002/chem.202404748 |
| Rights: |
CC-BY |
| Accession Number: |
edsbas.937DA4EA |
| Database: |
BASE |