| Title: |
Characteristics of Early-Onset vs Late-Onset Colorectal Cancer |
| Authors: |
Collaborative, REACCT; Zaborowski, Alexandra M; Abdile, Ahmed; Adamina, Michel; Aigner, Felix; d’Allens, Laura; Allmer, Caterina; Álvarez, Andrea; Anula, Rocio; Andric, Mihailo; Atallah, Sam; Bach, Simon; Bala, Miklosh; Barussaud, Marie; Bausys, Augustinas; Bebington, Brendan; Beggs, Andrew; Bellolio, Felipe; Bennett, Melissa-Rose; Berdinskikh, Anton; Bevan, Vicki; Biondo, Sebastiano; Bislenghi, Gabriele; Bludau, Marc; Boutall, Adam; Brouwer, Nelleke; Brown, Carl; Bruns, Christiane; Buchanan, Daniel D; Buchwald, Pamela; Burger, Jacobus WA; Burlov, Nikita; Campanelli, Michela; Capdepont, Maylis; Carvello, Michele; Chew, Hwee-Hoon; Christoforidis, Dimitri; Clark, David; Climent, Marta; Cologne, Kyle G; Contreras, Tomas; Croner, Roland; Daniels, Ian R; Dapri, Giovanni; Davies, Justin; Delrio, Paolo; Denost, Quentin; Deutsch, Michael; Dias, Andre; D’Hoore, André; Drozdov, Evgeniy; Duek, Daniel; Dunlop, Malcolm; Dziki, Adam; Edmundson, Aleksandra; Efetov, Sergey; El-Hussuna, Alaa; Elliot, Brodie; Emile, Sameh; Espin, Eloy; Evans, Martyn; Faes, Seraina; Faiz, Omar; Fleming, Fergal; Foppa, Caterina; Fowler, George; Frasson, Matteo; Figueiredo, Nuno; Forgan, Tim; Frizelle, Frank; Gadaev, Shamil; Gellona, Jose; Glyn, Tamara; Gong, Jianping; Goran, Barisic; Greenwood, Emma; Guren, Marianne G; Guillon, Stephanie; Gutlic, Ida; Hahnloser, Dieter; Hampel, Heather; Hanly, Ann; Hasegawa, Hirotoshi; Iversen, Lene Hjerrild; Hill, Andrew; Hill, James; Hoch, Jiri; Hoffmeister, Michael; Hompes, Roel; Hurtado, Luis; Iaquinandi, Fabiano; Imbrasaite, Ugne; Islam, Rumana; Jafari, Mehrenah Dorna; Kanemitsu, Yukihide; Karachun, Aleksei; Karimuddin, Ahmer A; Keller, Deborah S; Kelly, Justin; Kennelly, Rory |
| Source: |
JAMA Surgery, vol 156, iss 9 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2021 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
Aging; Nutrition; Digestive Diseases; Cancer; Colo-Rectal Cancer; Genetics; Clinical Research; Prevention; 2.1 Biological and endogenous factors; Aetiology; Good Health and Well Being; Adult; Age of Onset; Colorectal Neoplasms; Humans; Incidence; Middle Aged; Risk Factors; REACCT Collaborative |
| Subject Geographic: |
865 - 874 |
| Description: |
ImportanceThe incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer.ObservationsWithin the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts.Conclusions and relevanceThe clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt08d0d6hf; https://escholarship.org/uc/item/08d0d6hf; https://escholarship.org/content/qt08d0d6hf/qt08d0d6hf.pdf |
| DOI: |
10.1001/jamasurg.2021.2380 |
| Availability: |
https://escholarship.org/uc/item/08d0d6hf; https://escholarship.org/content/qt08d0d6hf/qt08d0d6hf.pdf; https://doi.org/10.1001/jamasurg.2021.2380 |
| Rights: |
public |
| Accession Number: |
edsbas.93A4F7D5 |
| Database: |
BASE |