| Title: |
Long COVID and cardiovascular disease: a prospective cohort study |
| Authors: |
Lawson, CA; Moss, AJ; Arnold, JR; Bagot, C; Banerjee, A; Berry, C; Greenwood, J; Hughes, AD; Khunti, K; Mills, NL; Neubauer, S; Raman, B; Sattar, N; Leavy, OC; Richardson, M; Elneima, O; McAuley, HJ; Shikotra, A; Singapuri, A; Sereno, M; Saunders, R; Harris, V; Houchen-Wolloff, L; Greening, NJ; Harrison, E; Docherty, AB; Lone, NI; Quint, JK; Chalmers, J; Ho, L-P; Horsley, A; Marks, M; Poinasamy, K; Evans, R; Wain, LV; Brightling, C; McCann, GP |
| Contributors: |
Group, PHOSP-COVID Study Collaborative |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known. Objectives: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors. Methods: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health. Results: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86). Conclusion: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need. Trail registration number: ISRCTN10980107. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/openhrt-2024-002662 |
| Availability: |
https://doi.org/10.1136/openhrt-2024-002662; https://ora.ox.ac.uk/objects/uuid:54751205-7045-49df-a1b5-7223e8db7dd4 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.942A567D |
| Database: |
BASE |