Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19: A Prospective, Multicenter, Cohort Study
| Title: | Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19: A Prospective, Multicenter, Cohort Study |
|---|---|
| Authors: | Shiwani H; Artico J; Moon JC; Gorecka M; McCann GP; Roditi G; Morrow A; Mangion K; Lukaschuk E; Shanmuganathan M; Miller CA; Chiribiri A; Alzahir M; Ramirez S; Lin A; Swoboda PP; McDiarmid AK; Sykes R; Singh T; Bucciarelli-Ducci C; Dawson D; Fontana M; Manisty C; Treibel TA; Levelt E; Arnold R; Young R; McConnachie A; Neubauer S; Piechnik SK; Davies RH; Ferreira VM; Dweck MR; Berry C; Greenwood JP; Dweck M; Miller CM; Prasad S; Davies R; Kelly B; Macfarlane PW; Goreka M; Somers K; Byrom-Goulthorp RJ; Anderson M; Britton L; Richards F; Jones LM; Moss A; Fisher J; Wormleighton J; Parke K; Wright R; Yeo J; Falconer J; Harries V; Henderson P; Newby D; Piechnik S; Popescu I; Zhang Q; Raman B; Channon K; Krasopoulos C; Nunes C; Da Silva Rodrigues L; Nixon H; Panopoulou A; Fletcher A; Manley P; Fallon K; Brown A; Kelly L; McGinley C; Briscoe M; Woodward R; Hopkins T; McLennan E; Tynan N; Dymock L; Swoboda P; Wright J; Exley D; Steeds R; Hutton K; MacDonald S; Treibel T; Shetye A; Orsborne C; Woodville-Jones W; Ferguson S; Bratis K; Fairbairn T; Sionas M; Widdows P; Chew PG; Marsden C; Collins T; George L; Kearney L; Flett A; Smith S; Zhenge A; Harvey J; Inacio L; Hanam-Penfold T; Gruner L; Razvi YSK; Crause J; Davies NM; Brown JT; Chaco L; Patel R; Kotecha T; Knight DS; Green T; Ripley D; Thompson M; Akerele U; Cifra E; Alskaf E; Crawley R; Villa A; Nightingale AK; Wright K; Bonnick ED; Hopkins E; George J; Joseph L; Cole G; Vimalesvaran K; Ali N; Carr CR; Ross AAR; King C; Farzad Z; Salmi SA; Kirby K; McDiarmid A; Stevenson HJ; Matsvimbo PS; Joji L; Fearby M; Brown B; Bunce N; Jennings R; Sookhoo V; Joshi S; Kanagala P; Fullalove S; Toohey C; Fenlon K; Bellenger N; He J; Statton S; Pamphilon N; Steele A; Ball C; McGahey A; Balma S; Wilkes L; Lewis K; Walter M; Ionescu A; Ninan T; Richards S; Williams M; Alfakih K; Pilgrim S; Joy G; Manisty CH; Hussain I |
| Source: | JACC: Cardiovascular Imaging, 2024 |
| Publisher Information: | Elsevier Inc. |
| Publication Year: | 2024 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © 2024 The AuthorsBackground: Hospitalized COVID-19 patients with troponin elevation have a higher prevalence of cardiac abnormalities than control individuals. However, the progression and impact of myocardial injury on COVID-19 survivors remain unclear. Objectives: This study sought to evaluate myocardial injury in COVID-19 survivors with troponin elevation with baseline and follow-up imaging and to assess medium-term outcomes. Methods: This was a prospective, longitudinal cohort study in 25 United Kingdom centers (June 2020 to March 2021). Hospitalized COVID-19 patients with myocardial injury underwent cardiac magnetic resonance (CMR) scans within 28 days and 6 months postdischarge. Outcomes were tracked for 12 months, with quality of life surveys (EuroQol-5 Dimension and 36-Item Short Form surveys) taken at discharge and 6 months. Results: Of 342 participants (median age: 61.3 years; 71.1% male) with baseline CMR, 338 had a 12-month follow-up, 235 had a 6-month CMR, and 215 has baseline and follow-up quality of life surveys. Of 338 participants, within 12 months, 1.2% died; 1.8% had new myocardial infarction, acute coronary syndrome, or coronary revascularization; 0.8% had new myopericarditis; and 3.3% had other cardiovascular events requiring hospitalization. At 6 months, there was a minor improvement in left ventricular ejection fraction (1.8% ± 1.0%; P < 0.001), stable right ventricular ejection fraction (0.4% ± 0.8%; P = 0.50), no change in myocardial scar pattern or volume (P = 0.26), and no imaging evidence of continued myocardial inflammation. All pericardial effusions (26 of 26) resolved, and most pneumonitis resolved (95 of 101). EuroQol-5 Dimension scores indicated an overall improvement in quality of life (P < 0.001). Conclusions: Myocardial injury in severe hospitalized COVID-19 survivors is nonprogressive. Medium-term outcomes show a low incidence of major adverse cardiovascular events and improved quality of life. (COVID-19 Effects on the Heart; ISRCTN58667920) |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/301166; https://eprints.ncl.ac.uk/fulltext.aspx?url=301166/B555D9DD-0002-476E-877B-930EDBC1BF76.pdf&pub_id=301166 |
| Availability: | https://eprints.ncl.ac.uk/301166 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.94613221 |
| Database: | BASE |