| Title: |
CKD progression, kidney failure, and mortality among US patients with IgA nephropathy |
| Authors: |
Sim, John J; Chen, Qiaoling; Cannizzaro, Nancy; Fernandes, Ancilla W; Pinto, Cibele; Bhandari, Simran K; Chang, John; Schachter, Asher D; Mathur, Mohit |
| Contributors: |
Otsuka Pharmaceutical Development and Commercialization |
| Source: |
Nephrology Dialysis Transplantation ; volume 40, issue 11, page 2104-2117 ; ISSN 0931-0509 1460-2385 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Background and Hypothesis We assessed disease progression among patients with immunoglobulin A nephropathy (IgAN) and characterized factors associated with risk for adverse outcomes. Methods A retrospective longitudinal cohort (2000–2022) study of adults with biopsy-confirmed IgAN within Kaiser Permanente Southern California was performed. The outcome of interest was a composite of ≥50% estimated glomerular filtration rate (eGFR) decline, kidney failure, or mortality. Cox proportional hazards regression modeling was used to estimate hazard ratios (HR) for the eGFR decline/kidney failure with adjustment for potential confounders. Results Among 655 patients with primary IgAN (31% Asian/Pacific Islander, 3% Black, 40% Hispanic/Latino, 24% White), 234 (36%) reached the composite outcome of ≥50% eGFR decline (17%), kidney failure (16%), or mortality (3%). The composite outcome occurred at a rate of 79.4 events (95% confidence intervals (CI) 69.6, 90.7) per 1000 patient-years, with a median time to event of 2.7 years. Compared to urine protein creatinine ratio (UPCR) |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ndt/gfaf084 |
| DOI: |
10.1093/ndt/gfaf084/63037461/gfaf084.pdf |
| Availability: |
https://doi.org/10.1093/ndt/gfaf084; https://academic.oup.com/ndt/advance-article-pdf/doi/10.1093/ndt/gfaf084/63037461/gfaf084.pdf; https://academic.oup.com/ndt/article-pdf/40/11/2104/65001737/gfaf084.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.9469104B |
| Database: |
BASE |