| Title: |
Point-of-care ultrasound reveals extensive pathology in Gabonese preschool-age children with urogenital schistosomiasis. |
| Authors: |
Remppis, Jonathan; Verheyden, Anais; Sultanli, Ayten; Bustinduy, Amaya Lopez; Heller, Tom; Adegnika, Ayola Akim; Grobusch, Martin Peter; Ramharter, Michael; Joekes, Elizabeth; Bélard, Sabine |
| Contributors: |
Chai, jong-Yil |
| Publisher Information: |
Public Library of Science (PLoS) |
| Publication Year: |
2025 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
BACKGROUND: Historically, urinary tract pathology caused by S. haematobium infection was thought to affect predominantly school-age children (SAC) and adults. Increasing availability of ultrasound data from endemic areas demonstrates that even younger children develop potentially irreversible pathology. METHODOLOGY/PRINCIPAL FINDINGS: Point-of-care ultrasound for urinary schistosomiasis and urine microscopy were performed across age groups in 105 patients with symptomatic urogenital schistosomiasis in Lambaréné, Gabon. Of 96 ultrasound scans with sufficient image quality, bladder wall thickening > 5mm was found in 9/20 (45%) preschool-age children (PSAC), 29/51 (57%) SAC and 7/25 (28%) adults. Upper urinary tract pathology was found in 19/90 (21%) patients across age groups, up from three years of age. Urine egg counts were highest in PSAC, with high-intensity infection (≥ 50 eggs/10 ml urine) in 19/24 (79%) and hyper-infection (≥ 500 eggs/10 ml urine) in 10/24 (42%). Bladder wall thickening > 5mm and upper urinary tract pathology correlated significantly with high-intensity infection with crude odds ratios of 8.6 (95% CI 3.1-23.8; p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1935-2727 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4675853/1/Remppis-etal-2025-Point-of-care-ultrasound-reveals-extensive-pathology-in-Gabonese-preschool-age-children-with-urogenital-schistosomiasis.pdf; https://researchonline.lshtm.ac.uk/id/eprint/4675853/7/Remppis-etal-2025-Point-of-care-ultrasound-reveals-extensive-pathology-in-Gabobese-preschool-age-children-with-urogenital-schistosomiasis.pdf; Remppis, JonathanORCID logo; Verheyden, Anais; Sultanli, Ayten; Bustinduy, Amaya Lopez ORCID logo; Heller, Tom; Adegnika, Ayola Akim; Grobusch, Martin Peter; Ramharter, Michael; Joekes, Elizabeth; and Bélard, Sabine (2025) Point-of-care ultrasound reveals extensive pathology in Gabonese preschool-age children with urogenital schistosomiasis. PLoS neglected tropical diseases, 19 (4). e0012991-. ISSN 1935-2727 DOI:10.1371/journal.pntd.0012991 |
| DOI: |
10.1371/journal.pntd.0012991 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4675853/; https://doi.org/10.1371/journal.pntd.0012991 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.947EB7C1 |
| Database: |
BASE |