| Title: |
Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity |
| Authors: |
Hrdlickova, Barbara; Kumar, Vinod; Kanduri, Kartiek; Zhernakova, Daria V.; Tripathi, Subhash; Karjalainen, Juha; Lund, Riikka J.; Li, Yang; Ullah, Ubaid; Modderman, Rutger; Abdulahad, Wayel; Lahdesmaki, Harri; Franke, Lude; Lahesmaa, Riitta; Wijmenga, Cisca; Withoff, Sebo |
| Source: |
Hrdlickova, B, Kumar, V, Kanduri, K, Zhernakova, D V, Tripathi, S, Karjalainen, J, Lund, R J, Li, Y, Ullah, U, Modderman, R, Abdulahad, W, Lahdesmaki, H, Franke, L, Lahesmaa, R, Wijmenga, C & Withoff, S 2014, 'Expression profiles of long non-coding RNAs located in autoimmune disease-associated regions reveal immune cell-type specificity', Genome medicine, vol. 6, no. 10, 88. https://doi.org/10.1186/s13073-014-0088-0 |
| Publication Year: |
2014 |
| Collection: |
University of Groningen research database |
| Subject Terms: |
SUSCEPTIBILITY LOCI; RHEUMATOID-ARTHRITIS; GENETIC-VARIATION; SHARED GENETICS; CELIAC-DISEASE; RISK LOCI; TH1 CELLS; TGF-BETA; IDENTIFICATION; CANCER |
| Description: |
Background: Although genome-wide association studies (GWAS) have identified hundreds of variants associated with a risk for autoimmune and immune-related disorders (AID), our understanding of the disease mechanisms is still limited. In particular, more than 90% of the risk variants lie in non-coding regions, and almost 10% of these map to long non-coding RNA transcripts (lncRNAs). lncRNAs are known to show more cell-type specificity than protein-coding genes. Methods: We aimed to characterize lncRNAs and protein-coding genes located in loci associated with nine AIDs which have been well-defined by Immunochip analysis and by transcriptome analysis across seven populations of peripheral blood leukocytes (granulocytes, monocytes, natural killer (NK) cells, B cells, memory T cells, naive CD4(+) and naive CD8(+) T cells) and four populations of cord blood-derived T-helper cells (precursor, primary, and polarized (Th1, Th2) T-helper cells). Results: We show that lncRNAs mapping to loci shared between AID are significantly enriched in immune cell types compared to lncRNAs from the whole genome (a |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1756-994X |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/25419237; info:eu-repo/semantics/altIdentifier/wos/000345714400001; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/ca051e99-5085-4ce1-9b8d-7047850021fe; info:eu-repo/semantics/altIdentifier/pissn/1756-994X |
| DOI: |
10.1186/s13073-014-0088-0 |
| Availability: |
https://hdl.handle.net/11370/ca051e99-5085-4ce1-9b8d-7047850021fe; https://research.rug.nl/en/publications/ca051e99-5085-4ce1-9b8d-7047850021fe; https://doi.org/10.1186/s13073-014-0088-0; https://pure.rug.nl/ws/files/43846463/Expression_profiles_of_long_non_coding_RNAs_located_in_autoimmune.pdf |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.948FD15B |
| Database: |
BASE |