| Title: |
Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons |
| Authors: |
Rivier,Cyprien A.; Singh,Sanjula; Senff, Jasper; Tack, Reinier W.; Marini,Sandro; Clocchiatti-Tuozzo,Santiago; Huo,Shufan; Renedo,Daniela; Papier,Keren; Conroy,Megan; Littlejohns,Thomas J.; Chemali,Zeina; Kourkoulis,Christina; Payabvash,Seyedmehdi; Newhouse,Amy; Westover,M. Brandon; Lazar,Ronald M.; Pikula,Aleksandra; Ibrahim,Sarah; Howard,Virginia J.; Howard,George; Brouwers, H. Bart; Van Duijn,Cornelia M.; Fricchione,Gregory; Tanzi,Rudolph E.; Yechoor,Nirupama; Sheth,Kevin N.; Anderson,Christopher D.; Rosand,Jonathan; Falcone,Guido J.; Projectafdeling CVZ; Neurochirurgie |
| Publication Year: |
2024 |
| Subject Terms: |
Taverne; Clinical Neurology |
| Description: |
Objectives: To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury. Methods: This prospective cohort study in the UK Biobank assessed the BCS, a novel tool designed to empower patients to address 12 dementia and stroke risk factors. The BCS ranges from 0 to 21, with higher scores suggesting better brain care. Outcomes included white matter hyperintensities (WMH) volume, fractional anisotropy (FA), and mean diffusivity (MD) obtained during 2 imaging assessments, as well as their progression between assessments, using multivariable linear regression adjusted for age and sex. Results: We included 34,509 participants (average age 55 years, 53% female) with no stroke or dementia history. At first and repeat imaging assessments, every 5-point increase in baseline BCS was linked to significantly lower WMH volumes (25% 95% CI [23%-27%] first, 33% [27%-39%] repeat) and higher FA (18% [16%-20%] first, 22% [15%-28%] repeat), with a decrease in MD (9% [7%-11%] first, 10% [4%-16%] repeat). In addition, a higher baseline BCS was associated with a 10% [3%-17%] reduction in WMH progression and FA decline over time. Discussion: This study extends the impact of the BCS to neuroimaging markers of clinically silent cerebrovascular disease. Our results suggest that improving one's BCS could be a valuable intervention to prevent early brain health decline. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0028-3878 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/454853 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/454853 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.94A68002 |
| Database: |
BASE |