| Title: |
Description of the updated nutrition calculation of the Oxford WebQ questionnaire and comparison with the previous version among 207,144 participants in UK Biobank |
| Authors: |
Perez-Cornago, A; Pollard, Z; Young, H; van Uden, M; Andrews, C; Piernas, C; Key, TJ; Mulligan, A; Lentjes, M |
| Publisher Information: |
Springer |
| Publication Year: |
2026 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background & aims: Evidence on the association between nut consumption and depression is mainly based on cross-sectional studies. This study aims to analyse whether nut consumption is prospectively associated with the risk of depression in adults. Methods: This study was conducted using the United Kingdom (UK) Biobank resource. Data from middleaged and older UK adults who participated in this cohort between 2007e2012 (baseline) and 2013e2020 (follow-up) were analysed. Baseline information on nut consumption was obtained with the Oxford WebQ 24-h questionnaire. Depression, defined as a self-reported physician diagnosis of depression or antidepressant use, was assessed at baseline and follow-up. Hazard regression models estimating the predictive ability of nut consumption for the risk of developing depression were adjusted for sociodemographic, lifestyle, and health confounders. Results: A total of 13,504 participants (mean age 57.5 ± 7.2 years, 50.7% female) free of depression at baseline were included in the analyses. After a mean follow-up of 5.3 ± 2.4 years, 1122 (8.3%) incident cases of depression were identified. Compared with no nut consumption, the daily consumption of >0 to 1 serving of 30 g of nuts was associated with a lower risk of depression (hazard ratio, HR ¼ 0.83; 95% confidence interval, CI: 0.71e0.97) regardless of all potential confounders considered. In stratified analyses, a decreased risk of depression was more clearly observed in UK adults with adequate weight control, a healthy lifestyle, and better health status than in their counterparts (p < 0.05). Conclusions: Low-to-moderate nut consumption (>0 to 1 serving of 30 g/day) was associated with a 17% lower risk of depression during a 5.3-year follow-up compared with no nut consumption in a large sample of middle-aged and older UK adults. This protective association is enhanced in the absence of other known risk factors for depressio |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1007/s00394-021-02558-4 |
| Availability: |
https://doi.org/10.1007/s00394-021-02558-4; https://ora.ox.ac.uk/objects/uuid:d3930949-1616-4096-a78f-838a7027129e |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.94B00849 |
| Database: |
BASE |