| Title: |
Rare coding variants in ten genes confer substantial risk for schizophrenia |
| Authors: |
Singh, T; Poterba, T; Curtis, D; Akil, H; Al Eissa, M; Barchas, JD; Bass, N; Bigdeli, TB; Breen, G; Bromet, EJ; Buckley, PF; Bunney, WE; Bybjerg-Grauholm, J; Byerley, WF; Chapman, SB; Chen, WJ; Churchhouse, C; Craddock, N; Cusick, CM; DeLisi, L; Dodge, S; Escamilla, MA; Eskelinen, S; Fanous, AH; Faraone, SV; Fiorentino, A; Francioli, L; Gabriel, SB; Gage, D; Gagliano Taliun, SA; Ganna, A; Genovese, G; Glahn, DC; Grove, J; Hall, MH; Hämäläinen, E; Heyne, HO; Holi, M; Hougaard, DM; Howrigan, DP; Huang, H; Hwu, HG; Kahn, RS; Kang, HM; Karczewski, KJ; Kirov, G; Knowles, JA; Lee, FS; Lehrer, DS; Lescai, F; Malaspina, D; Marder, SR; McCarroll, SA; McIntosh, AM; Medeiros, H; Milani, L; Morley, CP; Morris, DW; Mortensen, PB; Myers, RM; Nordentoft, M; O’Brien, NL; Olivares, AM; Ongur, D; Ouwehand, WH; Palmer, DS; Paunio, T; Quested, D; Rapaport, MH; Rees, E; Rollins, B; Satterstrom, FK; Schatzberg, A; Scolnick, E; Scott, LJ; Sharp, SI; Sklar, P; Smoller, JW; Sobell, JL; Solomonson, M; Stahl, EA; Stevens, CR; Suvisaari, J; Tiao, G; Watson, SJ; Watts, NA; Blackwood, DH; Børglum, AD; Cohen, BM; Corvin, AP; Esko, T; Freimer, NB; Glatt, SJ; Hultman, CM; McQuillin, A; Palotie, A; Pato, CN; Pato, MT; Pulver, AE; St. Clair, D |
| Source: |
Nature , 604 pp. 509-516. (2022) |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2022 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in 10 genes as conferring substantial risk for schizophrenia (odds ratios of 3–50, P < 2.14 × 10−6) and 32 genes at a false discovery rate of |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10147248/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10147248/2/2022-01-19_schema-supplementary-information-publication.pdf; https://discovery.ucl.ac.uk/id/eprint/10147248/3/McQuillin_2022-02-15_schema-main-text-publication.pdf; https://discovery.ucl.ac.uk/id/eprint/10147248/ |
| Rights: |
open |
| Accession Number: |
edsbas.94E5632F |
| Database: |
BASE |