| Title: |
Medical Fabrics with Non‐Antibiotic, Supramolecular Antimicrobial Coatings: A Preventive Approach to Combat Biofilm Formation and Bacterial Dissemination |
| Authors: |
Diarrassouba, Adjara; Rekiki, Abdessalem; Loubière, Cécile; Kuchler‐bopp, Sabine; Petit, Lauriane; Calligaro, Cynthia; Mercer, Derry; Gaudin, Aurore; Canourgues, Naomi; Adicéam, Emilie; Beitz, Benoit; Welsch, Jeremy; Vigué, Annabelle; Kettel, Markus, J; Karl, Michael; Guilbaud-Chéreau, Chloe; Lavalle, Philippe; Vrana, Nihal, Engin; Hathroubi, Skander |
| Contributors: |
SPARTHA Medical; BIOASTER Microbiology Technology Institute Paris; BIOASTER Microbiology Technology Institute Lyon; Biomatériaux et Bioingénierie (BB); Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Matériaux et Nanosciences Grand-Est (MNGE); Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); Paul Hartmann SAS Lièpvre; Paul Hartmann AG Heidenheim; The authors would like to express their gratitude to the team at SPARTHA Medical for their valuable contributions to this work. Special thanks to Xavier Wurtz for his contributions to the illustrations. Authors would like to thank Vincent Ball (INSERM UNIT 1121) for his precious help for the FTIR experiments and Eric Mathieu (INSERM UNIT 1121) for the SEM images. Authors would also like to thank Yijie Li for the technical assistance on the coating process. This work was supported by the European Innovation Council (EIC) under the SPARTHACUS project (190184905) This project has received funding from the European Union's Horizon Europe Framework Programme under grant agreement number 10105855 (NOVA).; European Project: 190184905,HORIZON-EIC-2021-ACCELERATOROPEN-01,HORIZON-EIC-2021-ACCELERATOROPEN-01,SPARTHACUS(2022) |
| Source: |
ISSN: 2192-2640. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2026 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
wound infection; supramolecular assembly; medical device; hemocompatibility; coating; biopolymers; biofilm prevention; biocompatibility; antimicrobial peptides; antimicrobial peptides biocompatibility biofilm prevention biopolymers coating hemocompatibility medical device supramolecular assembly wound infection; [SDV.IB]Life Sciences [q-bio]/Bioengineering |
| Description: |
International audience ; Infections caused by bacterial colonization and biofilm formation on wounds and dressings present critical challenges to wound care, often impeding healing. Here, we report an antibiotic-free preventive strategy based on medical fabric coated with supramolecular antimicrobial assemblies. Using layer-by-layer dip coating technique, we functionalized medical fabric with polyarginine (PAR30) and hyaluronic acid (HA144) polymers, biopolymers that synergistically exhibited intrinsic antimicrobial activity. Coatings deposition and structural integrity were validated by confocal microscopy and ATR-FTIR spectroscopy. Antibacterial performance was assessed using the AATCC100 standard test method, showed strong efficacy against both Gram-negative and Gram-positive clinical pathogens. In vivo wound infection models, employing bioluminescent methicillinresistant Staphylococcus aureus (MRSA), were used to evaluate biofilm prevention. Coated and uncoated fabrics were either pre-inoculated with MRSA or applied to pre-infected wounds to assess their antimicrobial and anti-biofilm effects. The coated fabrics showed potent antibacterial activity, achieving ≥6 log-reduction in bacterial load within 24 h compared to uncoated fabrics. Bioluminescence imaging confirmed infection development in wounds covered with uncoated fabrics, while coated fabrics prevented infection with a ≥6 log-reduction in bacterial load on fabrics and a ≥4 log-reduction in wound biopsies. Additionally, coated fabrics inhibited biofilm formation and bacterial proliferation in wound beds inoculated with MRSA. Comprehensive in vitro and in vivo biocompatibility assessments demonstrated the safe profile of the coated fabrics for clinical use. These findings highlight the antimicrobial efficiency of coated fabrics in minimizing bacterial colonization and biofilm formation on wounds and textiles. This safe and effective first-in-class, innovative approach offers a promising preventive strategy against biofilm formation and addresses ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement//190184905/EU/Innovative multifunctional and smart coatings to prevent medical device related infections/SPARTHACUS |
| DOI: |
10.1002/adhm.202504888 |
| Availability: |
https://univoak.hal.science/hal-05619591; https://univoak.hal.science/hal-05619591v1/document; https://univoak.hal.science/hal-05619591v1/file/Adv%20Healthcare%20Materials%20-%202026%20-%20Diarrassouba%20-%20Medical%20Fabrics%20with%20Non%E2%80%90Antibiotic%20Supramolecular%20Antimicrobial%20Coatings.pdf; https://doi.org/10.1002/adhm.202504888 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.94ECEC1F |
| Database: |
BASE |