| Title: |
Comparing total-body metabolic PET imaging signatures of lung cancer cachexia to other wasting conditions |
| Authors: |
Brown, Emma; Duff, Lisa; Bernuzzi, Federico; Bielik, Robert; Alyamani, Abdullah; Vraka, Chrysoula; Peker, Nesibe; Edgar, Fraser; Soloviev, Dmitry; Vande Voorde, Johan; Lewis, David |
| Source: |
The PET is Wonderful Journal; Vol. 1 No. 1 (2024): PET is Wonderful 2024 Annual Scientific Meeting Abstracts ; 3049-8902 |
| Publisher Information: |
University of Edinburgh |
| Publication Year: |
2024 |
| Description: |
Cancer cachexia (CC) is a debilitating wasting condition. While anorexia and muscle wasting are features of cachexia, CC is a distinct and poorly understood metabolic syndrome1. We harnessed preclinical models of lung cancer to study how glucose uptake changes during CC and performed comparative analyses with anorexia and muscle wasting. Lung K-rasG12D/+;Lkb1-/-(KL) mice suffering CC were imaged using [18F]fluorodeoxyglucose (FDG) PET at 15-19% weight loss alongside K-ras wild-type (WT) non-tumour bearing controls. Mice were injected with 12-18MBq of FDG, imaging 80-100 minutes post injection with the Mediso nanoScan® PET/MRI 1T. In non-tumour bearing male animals, we modelled anorexia, muscle wasting, and circulation of cachexia factor GDF15 as follows, respectively: fasted overnight for 20 hr, treated with dexamethasone 21-phosphate (dexa) (2mg/kg, i.p. daily, 21 days) and single injection of recombinant human GDF15 hormone (0.1 mg/kg s.c.). FDG ex vivo biodistribution showed increased uptake in myocardium (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://journals.ed.ac.uk/PiWJournal/article/view/9969/12813; https://journals.ed.ac.uk/PiWJournal/article/view/9969 |
| DOI: |
10.2218/piwjournal.9969 |
| Availability: |
https://journals.ed.ac.uk/PiWJournal/article/view/9969; https://doi.org/10.2218/piwjournal.9969 |
| Rights: |
Copyright (c) 2024 Emma Brown, Lisa Duff, Federico Bernuzzi, Robert Bielik, Abdullah Alyamani, Chrysoula Vraka, Nesibe Peker, Fraser Edgar, Dmitry Soloviev, Johan Vande Voorde, David Lewis ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.95164CBB |
| Database: |
BASE |