| Title: |
Study of Protein-Protein Interactions in Septin Assembly: Multiple Amphipathic Helix Domains Cooperate in Binding to the Lipid Membrane |
| Authors: |
Mofidi, S. Mahsa; Sahoo, Abhilash; Edelmaier, Christopher J.; Klawa, Stephen J.; Freeman, Ronit; Gladfelter, Amy; Forest, M. Gregory; Nazockdast, Ehssan; Hanson, Sonya M. |
| Publisher Information: |
Zenodo |
| Publication Year: |
2025 |
| Collection: |
Zenodo |
| Subject Terms: |
septins; membrane curvature; amphipathic helix; molecular dynamics; lipid bilayer; protein-protein interaction; membrane remodeling |
| Description: |
This repository contains data, analysis scripts, and figures used in the study of amphipathic helix (AH) domains in septin assembly. Using all-atom molecular dynamics simulations, the work explores how single and multiple AH peptides interact with lipid bilayers, including membrane-induced curvature, peptide bending, lipid packing defects, and peptide-peptide interactions. The findings contribute to understanding cooperative membrane binding and septin filament formation. |
| Document Type: |
dataset |
| Language: |
unknown |
| Relation: |
https://github.com/flatironinstitute/septin_AH_analysis/tree/version1; https://zenodo.org/records/16790389; oai:zenodo.org:16790389; https://doi.org/10.5281/zenodo.16790389 |
| DOI: |
10.5281/zenodo.16790389 |
| Availability: |
https://doi.org/10.5281/zenodo.16790389; https://zenodo.org/records/16790389 |
| Rights: |
MIT License ; mit ; https://opensource.org/licenses/MIT |
| Accession Number: |
edsbas.955A6452 |
| Database: |
BASE |