| Title: |
The Evolution of Neo-Adjuvant Therapy in the Treatment of Oesophageal and Gastro-Oesophageal Junction Adenocarcinomas |
| Authors: |
Alexander A. Dermanis; Sivesh K. Kamarajah; Benjamin Tan |
| Source: |
Cancers, Vol 15, Iss 4741, p 4741 (2023) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2023 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
neoadjuvant; chemotherapy; radiotherapy; immunotherapy; adenocarcinoma; oesophagus; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282 |
| Description: |
Historically, oesophageal and gastro-oesophageal junction adenocarcinomas were associated with a poor prognosis. The advent of neoadjuvant therapy has transformed the management of oesophageal and gastro-oesophageal junction adenocarcinomas further and offers the possibility to reverse disease progression, eliminate micrometastasis, and offer potentially better outcomes for these patients. This review provides an overview of landmark clinical trials in this area, with different treatment regimens considered over the years as well as potential therapeutic agents on the horizon that may transform the management of oesophageal and gastro-oesophageal junction adenocarcinomas further. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2072-6694/15/19/4741; https://doaj.org/toc/2072-6694; https://doaj.org/article/816abf13675c4c05a4a507907718fd0f |
| DOI: |
10.3390/cancers15194741 |
| Availability: |
https://doi.org/10.3390/cancers15194741; https://doaj.org/article/816abf13675c4c05a4a507907718fd0f |
| Accession Number: |
edsbas.955FCF4D |
| Database: |
BASE |