| Title: |
Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation-study on behalf of CMWP of the EBMT. |
| Authors: |
Drozd-Sokołowska, J.; Gras, L.; Zinger, N.; Snowden, J. A.; Arat, M.; Basak, G.; Pouli, A.; Crawley, C.; Wilson, K. M. O.; Tilly, Hervé; Byrne, J.; Bulabois, Claude E.; Passweg, J.; Ozkurt, Z. N.; Schroyens, W.; Lioure, Bruno; Colorado Araujo, M.; Poiré, X.; Van Gorkom, G.; Gurman, G.; De Wreede, L. C.; Hayden, P. J.; Beksac, M.; Schönland, S. O.; Yakoub-Agha, Ibrahim |
| Contributors: |
Université de Lille; Inserm; CHU Lille; Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen CLCC Henri Becquerel; Université Grenoble Alpes UGA; Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286 |
| Publication Year: |
2024 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Description: |
Autologous hematopoietic cell transplantation (auto-HCT) may be performed in multiple myeloma (MM) patients relapsing after a previous auto-HCT. For those without an adequate dose of stored stem cells, remobilization is necessary. This retrospective study included patients who, following disease relapse after the first auto-HCT(s), underwent stem cell remobilization and auto-HCT performed using these cells. There were 305 patients, 68% male, median age at salvage auto-HCT was 59 years. The median time to relapse after the first-line penultimate auto-HCT(s) was 30.6 months, the median follow-up after salvage auto-HCT 31 months. The 2- and 4-year non-relapse mortality (NRM) after the salvage auto-HCT was 5 and 9%, the relapse incidence 56 and 76%, respectively. Overall survival (OS) after 2 and 4 years was 76 and 52%, progression-free survival (PFS) 39 and 15%. In multivariable analysis an increasing interval between the penultimate auto-HCT and relapse was associated with better OS and PFS, later calendar year of salvage auto-HCT with better OS. In conclusion, salvage auto-HCT performed with cells remobilized after a previous auto-HCT was associated with acceptable NRM. The leading cause of failure was disease progression of MM, which correlated with a shorter interval from the penultimate auto-HCT to the first relapse. ; 57 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream; application/rdf+xml; charset=utf-8; application/pdf |
| Language: |
English |
| Relation: |
Bone Marrow Transplantation; Bone Marrow Transplant; http://hdl.handle.net/20.500.12210/100892 |
| Availability: |
https://hdl.handle.net/20.500.12210/100892 |
| Rights: |
Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.958BA1BA |
| Database: |
BASE |