| Title: |
Derivation and internal validation of a mortality risk index for aged people living with HIV: The Dat'AIDS score. |
| Authors: |
Maxime Hentzien; Cyrille Delpierre; Pascal Pugliese; Clotilde Allavena; Christine Jacomet; Marc-Antoine Valantin; André Cabié; Lise Cuzin; David Rey; Firouzé Bani-Sadr; Moustapha Dramé; Dat’Aids Study Group |
| Source: |
PLoS ONE, Vol 13, Iss 4, p e0195725 (2018) |
| Publisher Information: |
Public Library of Science (PLoS) |
| Publication Year: |
2018 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Medicine; Science |
| Description: |
The objective was to develop a multivariable prognostic index for overall mortality over a five-year span integrating classical HIV biomarkers and comorbidities in people living with HIV (PLHIV) aged 60 or older.Prospective multicenter cohort study from the French Dat'AIDS cohort.All HIV-1 infected patients aged 60 years or older on 1st January 2008 were included. Sociodemographic data, CD4 cell count, CD4 nadir, HIV viral load, history of comorbidities, hepatitis co-infections and laboratory parameters at baseline were considered as potential prognostic variables. Primary outcome was all-cause mortality.Among 1415 patients included, we derived a score comprising the following predictors: Age (65-74: 1 point; ≥75: 8 points), CD4 cell count (200-349: 3 points; |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://europepmc.org/articles/PMC5908189?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/61a0d7de24524e19a54f455192fcdf6a |
| DOI: |
10.1371/journal.pone.0195725 |
| Availability: |
https://doi.org/10.1371/journal.pone.0195725; https://doaj.org/article/61a0d7de24524e19a54f455192fcdf6a |
| Accession Number: |
edsbas.95AF0499 |
| Database: |
BASE |