| Title: |
Biocompatible nanoparticles containing hydrophobic nickel-bis(dithiolene) complexes for NIR-mediated doxorubicin release and photothermal therapy |
| Authors: |
Ciancone, Mathieu; Mebrouk, Kenny; Bellec, Nathalie; Le Goff-Gaillard, Catherine; Arlot-Bonnemains, Yannick; Benvegnu, Thierry; Fourmigué, Marc; Camerel, Franck; Cammas-Marion, Sandrine |
| Contributors: |
Institut des Sciences Chimiques de Rennes (ISCR); Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes); Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); Institut de Génétique et Développement de Rennes (IGDR); Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); CNRS; Ecole Nationale Superieure de Chimie de Rennes; University of Rennes 1; la Ligue Contre le Cancer Grand Ouest |
| Source: |
ISSN: 2050-750X ; Journal of materials chemistry B ; https://univ-rennes.hal.science/hal-01771086 ; Journal of materials chemistry B, 2018, 6 (12), pp.1744-1753. ⟨10.1039/c7tb03289g⟩. |
| Publisher Information: |
HAL CCSD; Royal Society of Chemistry |
| Publication Year: |
2018 |
| Collection: |
Université de Rennes 1: Publications scientifiques (HAL) |
| Subject Terms: |
Photothermal therapy; nickel-bis(dithiolene) complex; Biocompatible nanoparticles; Biodegradable block copolymers; Photothermal Controlled Drug Release; [CHIM.MATE]Chemical Sciences/Material chemistry; [CHIM.THER]Chemical Sciences/Medicinal Chemistry; [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology |
| Description: |
International audience ; Biocompatible nanoparticles (NPs) constituted by amphiphilic poly(ethylene glycol)-block-poly(benzyl malate), PEG-b-PMLABe, have been designed for site-specific PhotoThermal Controlled Release (PTCR) of drugs thanks to the presence of a near infra-red (NIR) photothermally active nickel-bis(dithiolene) complex in the inner core of the NPs, together with doxorubicin (Dox). A nanoprecipitation technique was used to prepare well-defined nickel-bis(dithiolene) and nickel-bis(dithiolene)/Dox loaded NPs, which were characterized by dynamic light scattering (DLS), zeta-potential measurements and Transmission Electron Microscopy (TEM). We have shown that the Dox release was effectively controlled by NIR irradiation (long or pulsed NIR laser irradiation). Cytotoxicity experiments on HeLa and MDA-MB-231 cells have shown that the incorporation of more than 10 w% of nickel-bis(dithiolene) complexes does not increase the intrinsic toxicity of the polymer nanoparticles. Finally, the viability of MDA-MB-231 cells was assessed after their incubation, for 24 hours, with empty NPs, Ni4C(12) loaded NPs, Dox loaded NPs or Ni4C(12)/Dox loaded NPs, without or with NIR irradiation. Above all, the results have highlighted that the Ni4C(12) loaded NPs after 5 min NIR laser irradiation can induce strong cell death up to 80% at 50 g mL(-1). These results demonstrate that these NPs are good candidates for photothermal therapy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32254246; PUBMED: 32254246 |
| DOI: |
10.1039/c7tb03289g |
| Availability: |
https://univ-rennes.hal.science/hal-01771086; https://univ-rennes.hal.science/hal-01771086v1/document; https://univ-rennes.hal.science/hal-01771086v1/file/Ciancone%20-%20Biocompatible%20nanoparticles%20containing%20hydrophobic.pdf; https://doi.org/10.1039/c7tb03289g |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.95D4133F |
| Database: |
BASE |