| Title: |
Post-Discharge Worsening Renal Function in Patients with Type 2 Diabetes and Recent Acute Coronary Syndrome |
| Authors: |
Morici N; Savonitto S; Ponticelli C; Schrieks IC; Nozza A; Cosentino F; Stähli BE; Perrone Filardi P; Schwartz GG; Mellbin L; Lincoff AM; Tardif JC; Grobbee DE |
| Contributors: |
Morici, N; Savonitto, S; Ponticelli, C; Schrieks, Ic; Nozza, A; Cosentino, F; Stähli, Be; Perrone Filardi, P; Schwartz, Gg; Mellbin, L; Lincoff, Am; Tardif, Jc; Grobbee, De |
| Publisher Information: |
Elsevier Inc. |
| Publication Year: |
2017 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
acute coronary syndrome; diabetes mellitu; worsening renal function |
| Description: |
Background Worsening renal function during hospitalization for an acute coronary syndrome is strongly predictive of in-hospital and long-term outcome. However, the role of post-discharge worsening renal function has never been investigated in this setting. Methods We considered the placebo cohort of the AleCardio trial comparing aleglitazar with standard medical therapy among patients with type 2 diabetes mellitus and a recent acute coronary syndrome. Patients who had died or had been admitted to hospital for heart failure before the 6-month follow-up, as well as patients without complete renal function data, were excluded, leaving 2776 patients for the analysis. Worsening renal function was defined as a >20% reduction in estimated glomerular filtration rate from discharge to 6 months, or progression to macroalbuminuria. The Cox regression analysis was used to determine the prognostic impact of 6-month renal deterioration on the composite of all-cause death and hospitalization for heart failure. Results Worsening renal function occurred in 204 patients (7.34%). At a median follow-up of 2 years the estimated rates of death and hospitalization for heart failure per 100 person-years were 3.45 (95% confidence interval [CI], 2.46-6.36) for those with worsening renal function, versus 1.43 (95% CI, 1.14-1.79) for patients with stable renal function. At the adjusted analysis worsening renal function was associated with the composite endpoint (hazard ratio 2.65; 95% CI, 1.57-4.49; P |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28344139; info:eu-repo/semantics/altIdentifier/wos/WOS:000408157300040; volume:130; issue:9; firstpage:1068; lastpage:1075; numberofpages:8; journal:THE AMERICAN JOURNAL OF MEDICINE; http://hdl.handle.net/11573/1092016 |
| DOI: |
10.1016/j.amjmed.2017.02.033 |
| Availability: |
http://hdl.handle.net/11573/1092016; https://doi.org/10.1016/j.amjmed.2017.02.033 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.95EDFDAE |
| Database: |
BASE |