| Title: |
Influence of single and concurrent clofibrate and phenobarbital administration on cytochrome P450‐dependent mixed function oxidase activities and peroxisome proliferation in male rat liver |
| Authors: |
Close, Ian; Shackleton, Gareth; Goldfarb, Peter S.; Gibson, G. Gordon; Sharma, Raj; Howes, Doug |
| Source: |
Journal of Biochemical Toxicology ; volume 7, issue 3, page 193-198 ; ISSN 0887-2082 1522-7146 |
| Publisher Information: |
Wiley |
| Publication Year: |
1992 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
The influence of both single and concurrent administration of phenobarbital and clofibrate on hepatomegaly, cytochrome P450‐depen‐dent mixed function oxidase activities, and peroxisome proliferation in male rat liver have been studied. Both xenobiotics separately increase the liver :body weight ratio and their combined administration results in greater hepatomegaly than either compound alone. Both compounds induce NADPH‐cytochrome c(P450) reductase activity and laurate ω‐ and ω‐1‐hydroxylase activities, but only phenobarbital induces pentoxyresorufin‐O‐de‐alkylase. None of the drug treatments induced microsomal cytochrome b5. Phenobarbital did not cause peroxisome proliferation and inhibited the corresponding clofibrate‐dependent proliferation. Taken collectively, our studies have demonstrated that concomitant treatment with phenobarbital and clofibrate are largely permissive with respect to the hepatic mixed function oxidase system but have opposing effects on the phenomenon of peroxisome proliferation in the same tissue. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/jbt.2570070309 |
| Availability: |
https://doi.org/10.1002/jbt.2570070309; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbt.2570070309; https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbt.2570070309 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.9636D8FD |
| Database: |
BASE |