| Title: |
Endoscopic ultrasound-guided pancreatic cavitation: Proof-of-Concept in a vascularized human cadaveric model |
| Authors: |
Beye, Birane; Rohfritsch, Adrien; Gannon, Jessica; Drainville, Andrew; Simonneau, Marine; Bibaki, Giovanna; Marcellier, Gabriel; Renault, Gilles; Woodacre, Jeffrey; Pioche, Mathieu; Lafond, Maxime; Lafon, Cyril; Prat, Frédéric |
| Contributors: |
Endoscopy Unit, Hepatogastroenterology department - Orleans University Hospital, Orléans, France; LabTAU, INSERM, Centre Léon Bérard, Université Claude Bernard Lyon 1, F-69003, Lyon, France; Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA; Life Imaging Facility, Paris-Cité University, PIV Platform, Institut Cochin, Paris, France; Endoscopy Department, Beaujon Hospital, AP-HP, Paris-Cité University, UMR 1149, Paris, France; Daxsonics Ultrasound, Halifax, Nova Scotia, Canada; This work was carried out with financial support from EUROSTARS (grant 115393 EDUCAIT) and from ITMO Cancer of Aviesan on funds administered by Inserm through the program PCSI Cancer 2020.; European Project: 115393,EDUCAIT |
| Source: |
https://hal.science/hal-05446152 ; 2026. |
| Publisher Information: |
CCSD |
| Publication Year: |
2026 |
| Collection: |
HAL Lyon 1 (University Claude Bernard Lyon 1) |
| Subject Terms: |
Focused ultrasound (FUS) ultrasonic cavitation pancreatic adenocarcinoma; Focused ultrasound (FUS); ultrasonic cavitation; pancreatic adenocarcinoma; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.IB]Life Sciences [q-bio]/Bioengineering |
| Description: |
Background: Pancreatic ductal adenocarcinoma's poor prognosis is due in part to its desmoplastic tumor microenvironment (TME), which hinders the bioavailability of anti-tumor drugs. Selectively targeting the physical properties of TME by ultrasonic cavitation could make systemic therapies more effective. We have designed an endoscopic ultrasound prototype capable to reach pancreatic parenchyma. The aim of this study was to demonstrate the feasibility of inducing cavitation in the pancreas with this prototype.Materials and methods: We prepared 5 cadaveric models: 3 non-perfused, and 2 perfused with the Sim-Life technology based on revascularization of human cadaver with a blood avatar. This technology allowed microbubbles to be injected to enhance cavitation. The device was positioned into the stomach via transesophageal approachResults: These tests confirmed that transesophageal navigation of the prototype into the stomach was feasible in the human cadaveric model. This not only enabled targeting pancreatic parenchyma, but also to successfully create ultrasonic cavitation in the pancreatic gland by delivering ultrasound combined with microbubbles.Conclusion: Our work establishes a proof-of-concept for the generation of cavitation in the pancreas of a perfused human cadaveric model using an echoendoscope, and paves the way for preliminary clinical work with a prospect of Endosonographic delivery of cavitation to pancreatic cancer. |
| Document Type: |
report |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement//115393/EU/EUROSTARS/EDUCAIT |
| Availability: |
https://hal.science/hal-05446152; https://hal.science/hal-05446152v1/document; https://hal.science/hal-05446152v1/file/Preprint_article_Simedys.pdf |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.963B19C8 |
| Database: |
BASE |