| Title: |
Geospatial mapping of drug-resistant tuberculosis prevalence in Africa at national and sub-national levels |
| Authors: |
Liyew, Alemneh Mekuriaw; Clements, Archie C A; Wagnew, Fasil; Gilmour, Beth; Alene, Kefyalew Addis |
| Source: |
Liyew, A M, Clements, A C A, Wagnew, F, Gilmour, B & Alene, K A 2025, 'Geospatial mapping of drug-resistant tuberculosis prevalence in Africa at national and sub-national levels', International Journal of Infectious Diseases, vol. 153, 107777. https://doi.org/10.1016/j.ijid.2025.107777 |
| Publication Year: |
2025 |
| Collection: |
Queen's University Belfast: Research Portal |
| Subject Terms: |
Geospatial mapping; drug-resistant tuberculosis; Africa; tuberculosis; /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: |
Objective To map subnational and local prevalence of drug-resistant tuberculosis (DR-TB) across Africa. Methods We assembled a geolocated dataset from 173 sources across 31 African countries, comprising drug susceptibility test results and covariate data from publicly available databases. We used Bayesian model-based geostatistical framework with multivariate Bayesian logistic regression model to estimate DR-TB prevalence at lower administrative levels. Results We estimated 148,239 DR-TB cases (95% Uncertainty Interval [UI]: 17,499- 313,683) in Africa, showing significant variation by country. Eswatini and South Africa had highest case numbers, while Algeria and Egypt had the lowest. The highest DR-TB prevalence was estimated in Eswatini (53.26; 95%UI 13.13-66.12), Morocco, Tunisia, and South Africa, while the lowest prevalence was found in Gabon, the Republic of Congo, Sierra Leone, and Mali. Marked subnational variation in DR-TB prevalence was noted, where 91 subnational areas across 12 countries had prevalence rates higher than their respective national averages. Factors such as mean temperature (β=2.01; 95% CrI: 1.21, 3.42), population density (β=0.41; 95% CrI: 0.19, 0.95), and fine particulate matter (β=0.66; 95% CrI: 0.20, 0.80) were positively associated with DR-TB prevalence. Conclusion The study highlights substantial national and subnational variability in DR-TB prevalence across Africa, aiding policymakers in designing localized TB control interventions. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1201-9712; 1878-3511 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pissn/1201-9712; info:eu-repo/semantics/altIdentifier/eissn/1878-3511 |
| DOI: |
10.1016/j.ijid.2025.107777 |
| Availability: |
https://pure.qub.ac.uk/en/publications/64682752-e98a-418f-98e9-d08f6d5262f2; https://doi.org/10.1016/j.ijid.2025.107777; https://pureadmin.qub.ac.uk/ws/files/631087069/PIIS1201971225000013.pdf |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.9647A2E2 |
| Database: |
BASE |