| Title: |
Metabolomic analysis of vitamin E supplement use in the prostate, lung, colorectal, and ovarian cancer screening trial |
| Authors: |
Lim, J; Hong, HGG; Weinstein, SJ; Playdon, MC; Cross, AJ; Stolzenberg-Solomon, R; Freedman, ND; Huang, J; Albanes, D |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2023 |
| Collection: |
Imperial College London: Spiral |
| Description: |
The effects of vitamin E supplementation on cancer and other chronic diseases are not clear. We compared the serum metabolomic profile of differing vitamin E dosages in order to re-examine the previously observed changes in a novel C22 lactone sulfate compound, androgenic steroids, and other metabolites. A total of 3409 women and men previously selected for metabolomics studies in the PLCO Cancer Screening Trial were included in this investigation. Serum metabolites were profiled using ultrahigh-performance liquid and gas chromatography/tandem mass spectrometry. Seventy known metabolites including C22 lactone sulfate and androgens were significantly associated with vitamin E supplementation. In the sex-stratified analysis, 10 cofactors and vitamins (e.g., alpha-CEHC sulfate and alpha-CEHC glucuronide), two carbohydrates (glyceric and oxalic acids), and one lipid (glycocholenate sulfate) were significantly associated with vitamin E dose in both males and females (FDR-adjusted p-value < 0.01). However, the inverse association between C22 lactone sulfate and daily vitamin E supplementation was evident in females only, as were two androgenic steroids, 5-androstenediol and androsterone glucuronide. Our study provides evidence of distinct steroid hormone pathway responses based on vitamin E dosages. Further studies are needed to gain biological insights into vitamin E biochemical effects relevant to cancer and other chronic diseases. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Nutrients; http://hdl.handle.net/10044/1/108129 |
| DOI: |
10.3390/nu15132836 |
| Availability: |
http://hdl.handle.net/10044/1/108129; https://doi.org/10.3390/nu15132836 |
| Rights: |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.964D035 |
| Database: |
BASE |