| Title: |
Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies |
| Authors: |
Roark, Ryan S.; Habib, Rumi; Gorman, Jason; Li, Hui; Connell, Andrew Jesse; Bonsignori, Mattia; Guo, Yicheng; Hogarty, Michael P.; Olia, Adam S.; Sowers, Kirsten J.; Zhang, Baoshan; Bibollet-Ruche, Frederic; Bylund, Tatsiana; Callaghan, Sean; Carey, John W.; Cerutti, Gabriele; Harris, Darcy R.; He, Wanting; Lewis, Emily; Liu, Tracy; Mason, Rosemarie D.; Qiao, Yujie; Park, Younghoon; Rando, Juliette M.; Singh, Ajay; Wolff, Jeremy J.; Lei, Q. Paula; Louder, Mark K.; Andrabi, Raiees; Doria-Rose, Nicole A.; Saunders, Kevin O.; Seaman, Michael S.; Haynes, Barton F.; Kulp, Daniel W.; Mascola, John R.; Roederer, Mario; Pierson, Theodore C.; Sheng, Zizhang; Hahn, Beatrice H.; Shaw, George M.; Kwong, Peter D.; Shapiro, Lawrence |
| Contributors: |
Bill & Melinda Gates Foundation; National Institutes of Health; Vaccine Research Center; National Institute of Allergy and Infectious Diseases; Duke Consortium for HIV Vaccine Development; Penn Center for AIDS Research; Training Grant in HIV Pathogenesis; Division of Intramural Research; Duke Human Vaccine Institute |
| Source: |
Journal of Experimental Medicine ; volume 222, issue 10 ; ISSN 0022-1007 1540-9538 |
| Publisher Information: |
Rockefeller University Press |
| Publication Year: |
2025 |
| Description: |
Broadly neutralizing antibodies targeting the V2 apex of HIV-1 envelope are desired as vaccine design templates, but few have been described. Here, we report 11 lineages of V2 apex–neutralizing antibodies from simian-human immunodeficiency virus (SHIV)-infected rhesus macaques and determine cryo-EM structures for 9. A single V2 apex–neutralizing lineage accounted for cross-clade breadth in most macaques, and somatic hypermutation relative to breadth was generally low, exemplified by antibody V033-a.01 with |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1084/jem.20250638 |
| DOI: |
10.1084/jem.20250638/1948921/jem_20250638.pdf |
| Availability: |
https://doi.org/10.1084/jem.20250638; https://rupress.org/jem/article-pdf/doi/10.1084/jem.20250638/1948921/jem_20250638.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.966E2FB2 |
| Database: |
BASE |