| Title: |
Clinical and Prognostic Factors Associated With Inflammatory Bowel Disease in a Highly Admixed Population With Primary Sclerosing Cholangitis |
| Authors: |
Nardelli, Mateus Jorge; Cançado, Guilherme Grossi Lopes; Barros, Luísa Leite; Dotta, Diogo Delgado; Faria, Luciana Costa; Rotman, Vivian; Villela-Nogueira, Cristiane Alves; Ferraz, Maria Lucia Gomes; Rocco, Rodrigo; Felga, Guilherme Eduardo; Martins, Adrielly de Souza; Codes, Liana; Mendes, Liliana Sampaio Costa; Silva, Marlone Cunha da; Hyppolito, Elodie Bonfim; Gomide, Geisa Perez Medina; Signorelli, Izabelle Venturini; Oliveira, Maria Beatriz de; Ivantes, Claudia Alexandra Pontes; Chiara, Maria; Borges, Valéria Ferreira de Almeida e; Terrabuio, Débora Raquel Benedita; Cançado, Eduardo Luiz Rachid; Bittencourt, Paulo Lisboa; Couto, Claudia Alves |
| Source: |
Journal of Clinical Gastroenterology ; ISSN 1539-2031 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2025 |
| Description: |
Goals: To investigate the prevalence of inflammatory bowel disease (IBD) in a cohort of Brazilian patients with primary sclerosing cholangitis (PSC) and evaluate clinical and prognostic factors associated with concomitant IBD. Background: IBD is reported worldwide in 62% to 81% of patients with PSC, especially in males and north Europeans. Little is known about the association of IBD and PSC in population from multigenetic ethnic origin. Study: Data of PSC patients from the Brazilian Cholestasis Study Group database were retrospectively reviewed to compare demographic, clinical, laboratory, and transplant-free survival between those with and without IBD. Results: After exclusion of 59 (14%) participants with overlap syndrome with autoimmune hepatitis, 359 individuals with PSC were included {56% male, median age 44 [interquartile range (IQR): 33 to 54] y}. IBD was investigated in 298 (83%) participants and diagnosed in 217 (73%), including ulcerative colitis (83%), Crohn’s disease (13%), and indeterminate colitis (4%). Male sex frequency was similar in patients with and without IBD (58% vs. 47%, P =0.073). IBD was more frequently diagnosed in patients without obesity ( P =0.035), positive for antinuclear antibody ( P =0.006), and positive for anti-smooth muscle antibody ( P =0.046). IBD diagnosis occurred before, concomitant, or after PSC diagnosis in 59%, 22%, and 19% of cases, respectively. IBD was more frequently diagnosed before PSC in participants asymptomatic for liver disease ( P =0.017), without advanced liver disease ( P =0.017), before liver transplantation (LT) ( P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/mcg.0000000000002253 |
| DOI: |
10.1097/MCG.0000000000002253 |
| Availability: |
https://doi.org/10.1097/mcg.0000000000002253; https://journals.lww.com/10.1097/MCG.0000000000002253 |
| Accession Number: |
edsbas.968341CC |
| Database: |
BASE |